http://www.fpnotebook.com/

Bicarbonate Supplementation

Aka: Bicarbonate Supplementation, Polycitra, Shohl Solution, Oral Sodium Bicarbonate

See Also
1. Intravenous Sodium Bicarbonate for Resuscitation
Indications
1. Renal Tubular Acidosis
Oral Preparations for Renal Tubular Acidosis
1. Potassium Citrate (Polycitra)
  1. Concentration: 500 mg per 5 ml
  2. Base Concentration: 2 meq per 1 ml
2. Oral Sodium Bicarbonate (325 mg and 650 mg tablets)
  1. Base Concentration: 4 meq per 325 mg tablet
3. Citric Acid (Shohl Solution)
  1. Concentration: 140 grams per 1000 ml
  2. Base concentration: 1 meq per 1 ml
Oral Dosing in Renal Tubular Acidosis
1. Distal RTA (low dose): 1-2 meq/kg/day
2. Proximal RTA (high dose): 10-15 meq/kg/day

Citric Acid / sodium citrate (C0304465)
Concepts	Organic Chemical (T109) , Pharmacologic Substance (T121)
SnomedCT	24772003
English	CITRIC ACID/SODIUM CITRATE, Citric Acid-Sodium Citrate, citric acid-sodium citrate, sodium citrate + citric acid (medication), sodium citrate + citric acid, Citric Acid / sodium citrate, acid citrate citric sodium, shohl's solution, sodium citrate citric acid, Shohl's solution, Sodium citrate and citric acid, Sodium citrate and citric acid (substance)
Spanish	citrato de sodio y ácido cítrico (sustancia), citrato de sodio y ácido cítrico, solución de Shohl
Sources	Derived from the NIH UMLS (Unified Medical Language System)

Polycitra (C0722698)
Definition (NCI)	A combination of sodium citrate and potassium citrate with alkalizing and antiurolithic effects. Polycitra is metabolized to bicarbonates, thereby increasing urinary pH by increasing the excretion of free bicarbonate ions. A rise in urinary pH increases the solubility of cystine in the urine and the ionization of uric acid to more soluble urate ion. In addition, increased urinary citrate and pH decreases calcium ion activity by increasing calcium complexation to dissociated anions and thus decreasing the saturation of calcium oxalate. By increasing the level of plasma bicarbonate this agent also buffers excess hydrogen ion concentration and raises blood pH, thereby reversing the clinical manifestations of acidosis.
Concepts	Organic Chemical (T109) , Pharmacologic Substance (T121)
English	Polycitra, polycitra
Sources	Derived from the NIH UMLS (Unified Medical Language System)

Family Practice Notebook

Patients should address specific medical concerns with their physicians.

Although access to this page is not restricted, the information found here is intended for use by medical providers.

This page was written by Scott Moses, MD, last revised on 10/21/2007 and last published on 5/14/2013.

This is one of 5887 pages in the Family Practice Notebook