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Temazepam
Aka: Temazepam, Restoril- See Also
- Class
- Medium Acting Benzodiazepine
- Indications
- Insomnia with frequent awakening
- Dose
- Restoril 7.5 to 30 mg PO 1-2 hours before bedtime
- Pharmacokinetics
- Onset: 30-60 minutes
- Duration: 6-8 hours
- Half-Life: 8-12 hours
- Serum levels peak in 2-3 hours after oral dose
- Background
- Weekly Cost: $1-2
- Exception: 7.5 mg costs $200/month
- Advantages
- Less daytime Sedation or accumulation
- Disadvantages
- More risk of rebound Insomnia
- Equivalent dosing (for Benzodiazepine Withdrawal)
- Valium = Dose x1.0
- Phenobarbital = Dose x3.0
| Medication Costs | ||
|---|---|---|
| Temazepam (on 2/9/2012 at DrugStore.com) | ||
| Temazepam 15mg Capsules | #30 for $12.99 | ($0.43/unit) |
| Temazepam 30mg Capsules | #30 for $14.99 | ($0.50/unit) |
| Temazepam 22.5mg Capsules | #30 for $199.98 | ($6.67/unit) |
| Temazepam 7.5mg Capsules | #30 for $155.99 | ($5.20/unit) |
| Restoril (on 2/9/2012 at DrugStore.com) | ||
| Restoril 22.5mg Capsules | #30 for $348.75 | ($11.63/unit) |
| Restoril 7.5mg Capsules | #30 for $348.76 | ($11.63/unit) |
| Restoril 15mg Capsules | #30 for $368.93 | ($12.30/unit) |
| Restoril 30mg Capsules | #30 for $348.76 | ($11.63/unit) |
| FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. | ||
Temazepam (C0039468) |
|
|---|---|
| Definition (MSH) | A benzodiazepine that acts as a GAMMA-AMINOBUTYRIC ACID modulator and anti-anxiety agent. |
| Definition (NCI) | A benzodiazepine derivative with antidepressant, sedative, hypnotic and anticonvulsant properties. Temazepam potentiates the inhibitory activities of gamma-aminobutyric acid (GABA) by binding to the GABA receptor, located in the limbic, neocortical and mesencephalic reticular system. This increases the frequency of chloride channel opening events, allowing the flow of chloride ions into the neuron leading to membrane hyperpolarization and decreases neuronal excitability. |
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D013693 |
| SnomedCT | 321143008, 334023006, 387300007, 54705000 |
| English | 3-Hydroxydiazepam, Hydroxydiazepam, Methyloxazepam, Oxydiazepam, Temazepam, 3 Hydroxydiazepam, 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-, Temazepam [anaesthesia], Temazepam [anesthesia], Temazepam [hypnotic], 10-chloro-4-hydroxy-6-methyl-2-phenyl-3,6-diazabicyclo[5.4.0]undeca-2,8,10,12-tetraen-5-one, temazepam, Temazepam [anesthesia] (product), Temazepam [hypnotic] (product), temazepam (medication), TEMAZEPAM, Temazepam [Chemical/Ingredient], Temazepam (product), Temazepam (substance), Temazepam [anesthesia] (substance), Temazepam [hypnotic] (substance) |
| Swedish | Temazepam |
| Czech | temazepam |
| Finnish | Tematsepaami |
| Russian | GIDROKSIDIAZEPAM, METILOKSAZEPAM, TEMAZEPAM, KAMAZEPAM, ГИДРОКСИДИАЗЕПАМ, КАМАЗЕПАМ, МЕТИЛОКСАЗЕПАМ, ТЕМАЗЕПАМ |
| Spanish | temazepam [hipnótico], temazepam [anestésico] (producto), temazepam [anestésico], temazepam [hipnótico] (producto), temacepam (producto), temacepam (sustancia), temacepam, temazepam (sustancia), temazepam, Hidroxidiazepam, Metiloxazepam, Temazepam |
| Japanese | テマゼパム, ヒドロキシジアゼパム, メチルオキサゼパム |
| Polish | Temazepam |
| French | Témazépam |
| German | Hydroxydiazepam, Methyloxazepam, Temazepam, 3-Hydroxydiazepam, Oxydiazepam |
| Italian | Temazepam |
| Portuguese | Hidroxidiazepam, Metiloxazepam, Temazepam |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Restoril (C0723045) |
|
|---|---|
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D013693 |
| German | Restoril |
| English | restoril, Restoril, Mallinckrodt Brand of Temazepam, Novartis Brand of Temazepam |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |