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Nicotine Lozenge

Aka: Nicotine Lozenge
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  1. Precautions
    1. Pregnancy Category: D
  2. Preparations: Nicotine Lozenges
    1. Available over the counter in the United States
    2. Caution: Lozenges contain 25% more nicotine than the Nicotine Gum
    3. Heavy smokers: 4 mg
      1. Use of 25 Cigarettes per day
      2. First Cigarette within 30 minutes of awakening
    4. Moderate smokers: 2 mg
      1. Less than 25 Cigarettes per day
  3. Dosing
    1. Maximum: 20 lozenges daily
    2. Avoid food or drink 15 minutes before gum
      1. Avoid acidic foods and beverages 30 minutes prior to use
    3. Taper schedule
      1. Week 1-6: One lozenge every 1-2 hours
      2. Week 7-9: One lozenge every 2-4 hours
      3. Weeks 10-12: One lozenge every 4-8 hours
  4. Adverse effects
    1. Nausea
    2. Gastroesophageal Reflux
    3. Headache
  5. References
    1. Larzelere (2012) Am Fam Physician 85(6):591-8

Nicotine Lozenge (C1253423)

Definition (NCI) A hard candy-like tablet that contains a small dose of nicotine. The nicotine is absorbed through the lining of the mouth and goes into the blood. This helps stop nicotine cravings, and relieves symptoms that occur when a person is trying to quit smoking. A prescription is not needed for nicotine lozenges.
Definition (NCI) A lozenge preparation containing the alkaloid nicotine with nicotine replacement activity. Upon administration of the lozenge, nicotine is released and, although nicotine binds to nicotinic cholinergic receptors at the autonomic ganglia, adrenal medulla and at neuromuscular junctions as well, the binding of nicotine to the receptors in the central nervous system (CNS) appears to be responsible for the addictive nature of nicotine. Binding to CNS nicotinic acetylcholine receptors causes the release of the neurotransmitter dopamine which appears to be responsible for the addiction of nicotine. Administration of nicotine may prevent nicotine craving and may help with the withdrawal symptoms associated with smoking cessation.
Concepts Clinical Drug (T200)
MSH D061485
SnomedCT 391879005
English lozenges nicotine, nicotine lozenges, nicotine lozenge, Lozenge, Nicotine, Nicotine Lozenge, Lozenges, Nicotine, Nicotine Lozenges, Nicotine lozenges (product), Nicotine lozenges
Spanish nicotina, comprimido de disolución oral (producto), nicotina, comprimido de disolución oral
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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