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Intranasal Nicotine

Aka: Intranasal Nicotine, Nicotine Nasal Spray, Nicotrol NS
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  1. See Also
    1. Tobacco Abuse
    2. Nicotine Replacement
  2. Indications
    1. Tobacco Cessation
  3. Efficacy
    1. One year quit rate 25% (12% for Placebo)
    2. Best in obese heavy smokers and non-white patients
      1. Lerman (2004) Ann Intern Med 140:426-33
  4. Mechanism
    1. Rapidly absorbed via nasal mucosa
  5. Preparations
    1. Available only by prescription in the United States
    2. Concentration 10 mg/ml and provides 0.5 mg/spray
    3. Each bottle contains 10 ml
  6. Dosing
    1. One dose is 1 spray each nostril (1 mg Nicotine)
    2. Start 1-2 doses per hour while awake for 8 weeks
      1. Do not exceed 5 doses per hour (or more than 40 doses per day)
    3. Taper over the next month
    4. Minimum recommended: 8 doses (8 mg) per day
    5. Maximum: 40 doses (40 mg) per day
    6. Do not use more than 6 months total
  7. Contraindications
    1. Same as Nicotine Patch
    2. Bronchospasm
  8. Adverse Effects
    1. Nasal Irritation (90%): Rhinorrhea or sneezing
      1. Symptoms may be severe
      2. Often continues throughout course of use
    2. Throat irritation
    3. Nausea
    4. Watery eyes
    5. Cough
  9. Precautions
    1. Pregnancy Category D
    2. Greater abuse potential than Nicotine Patch or gum
  10. References
    1. Larzelere (2012) Am Fam Physician 85(6):591-8
Medication Costs
Nicotrol NS (on 2/9/2012 at DrugStore.com)
Nicotrol NS 10mg/ml Solution 10ml Bottle #4 for $207.10 ($51.78/unit)
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Nicotrol NS (C0939401)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
English Nicotrol NS
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Nicotine Nasal Spray (C1249285)

Definition (NCI) A nose spray that contains a small dose of nicotine, which enters the blood by being absorbed through the lining of the nose. This helps stop nicotine cravings and relieves symptoms that occur when a person is trying to quit smoking. A prescription is needed for nicotine nasal spray.
Definition (NCI) A nasal spray composed of an aqueous solution containing the alkaloid nicotine with nicotine replacement activity. Upon administration of the spray into the nostrils, nicotine is taken up from the nasal mucosa into the bloodstream. Although nicotine binds to nicotinic cholinergic receptors at the autonomic ganglia, adrenal medulla and at neuromuscular junctions as well, the binding of nicotine to the receptors in the central nervous system (CNS) appears to be responsible for the addictive nature of nicotine. Binding to CNS nicotinic acetylcholine receptors causes the release of the neurotransmitter dopamine which appears to be responsible for the addiction of nicotine. Administration of nicotine may prevent nicotine craving and may help with the withdrawal symptoms associated with smoking cessation.
Concepts Clinical Drug (T200)
MSH D061485
SnomedCT 387693009
English Nicotine Nasal Inhaler, nasal nicotine spray, nasal nicotine sprays, nicotine nasal spray, Nicotine Nasal Sprays, Spray, Nicotine Nasal, Nasal Sprays, Nicotine, Sprays, Nicotine Nasal, Nicotine Nasal Spray, Nasal Spray, Nicotine, Nicotine nasal spray (product), Nicotine nasal spray
Spanish aerosol nasal de nicotina (producto), aerosol nasal de nicotina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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