Benzodiazepine Equivalents

Aka: Benzodiazepine Equivalents, Barbiturate Equivalents, Sedative Equivalents

1. Indications
   1. Benzodiazepine Withdrawal
   2. Barbiturate withdrawal
   3. Sedative withdrawal
2. Preparations: Benzodiazepines Equivalents
   1. Alprazolam (Xanax)
      1. Alprazolam 0.5 mg is equivalent to 10 mg Diazepam
      2. Valium = Dose x20
      3. Phenobarbital = Dose x30
   2. Chlordiazepoxide (Librium, Limbitrol)
      1. Chlordiazepoxide 25 mg is equivalent to 10 mg Diazepam
      2. Valium = Dose x0.4
      3. Phenobarbital = Dose x1.2
   3. Clonazepam (Klonopin)
      1. Clonazepam 0.5 mg is equivalent to 10 mg Diazepam
      2. Valium = Dose x20
      3. Phenobarbital = Dose x7.5
   4. Flurazepam (Dalmane)
      1. Flurazepam 15-30 mg is equivalent to 10 mg Diazepam
      2. Valium = Dose x0.33
      3. Phenobarbital = Dose x2.0
   5. Halazepam (Paxipam)
      1. Halazepam 20 mg is equivalent to 10 mg Diazepam
      2. Valium = Dose x0.5
      3. Phenobarbital = Dose x0.75
   6. Lorazepam (Ativan)
      1. Lorazepam 1 mg is equivalent to 10 mg Diazepam
      2. Valium = Dose x10
      3. Phenobarbital = Dose x15.0
   7. Oxazepam (Serax) 60 mg
      1. Oxazepam 20 mg is equivalent to 10 mg Diazepam
      2. Valium = Dose x0.5
      3. Phenobarbital = Dose x3.0
   8. Temazepam (Restoril)
      1. Temazepam 20 mg is equivalent to 10 mg Diazepam
      2. Valium = Dose x0.5
      3. Phenobarbital = Dose x3.0
3. Preparations: Barbiturate Equivalents
   1. Butabarbital (Butisol)
      1. Valium = Dose x0.1
      2. Phenobarbital = Dose x0.3
   2. Pentobarbital (Nembutal)
      1. Valium = Dose x0.1
      2. Phenobarbital = Dose x0.3
   3. Secobarbital (Seconal)
      1. Valium = Dose x0.1
      2. Phenobarbital = Dose x0.3
   4. Phenobarbital
      1. Valium = Dose x0.33
4. Preparations: Miscellaneous Sedative Equivalents
   1. Glycerol: Meprobamate (Equanil)
      1. Valium= Dose x0.025
      2. Phenobarbital = Dose x0.075
   2. Piperidinedione: Glutethimide (Doriden)
      1. Valium = Dose x0.04
      2. Phenobarbital = Dose x0.12
   3. Quinazoline: Methaqualone
      1. Valium = Dose x0.03
      2. Phenobarbital = Dose x0.1
5. References
   1. Ashton (2005) Curr Opin Psychiatry 18:249-55
   2. Tauseef (2012) BJMP 5(1): a501