Charlson Comorbidity Index

1. Indication
   1. Assess whether a patient will live long enough to benefit from a specific screening measure or medical intervention
2. Scoring: Comorbidity Component (Apply 1 point to each unless otherwise noted)
   1. Myocardial Infarction
   2. Congestive Heart Failure
   3. Peripheral Vascular Disease
   4. Cerebrovascular Disease
   5. Dementia
   6. COPD
   7. Connective Tissue Disease
   8. Peptic Ulcer Disease
   9. Diabetes Mellitus (1 point uncomplicated, 2 points if end-organ damage)
   10. Moderate to Severe Chronic Kidney Disease (2 points)
   11. Hemiplegia (2 points)
   12. Leukemia (2 points)
   13. Malignant Lymphoma (2 points)
   14. Solid Tumor (2 points, 6 points if metastatic)
   15. Liver Disease (1 point mild, 3 points if moderate to severe)
   16. AIDS (6 points)
3. Scoring: Age
   1. Age <40 years: 0 points
   2. Age 41-50 years: 1 points
   3. Age 51-60 years: 2 points
   4. Age 61-70 years: 3 points
   5. Age 71-80 years: 4 points
4. Interpretation
   1. Calculate Charlson Score or Index (i)
      1. Add Comorbidity score to age score
      2. Total denoted as 'i' below
   2. Calculate Charlson Probablity (10 year mortality)
      1. Calculate Y = e^(i * 0.9)
      2. Calculate Z = 0.983^Y
      3. where Z is the 10 year survival
5. References
   1. Charlson (1987) J Chron Dis 40: 373–83
   2. Gold (1994) J Clin Epidemiol 47: 1245–51