II. Definition

  1. Patients with negative test that do not have disease
  2. P(No Disease | negative test )
  3. Assesses reliability of negative test

III. Indications

  1. Puts Test Sensitivity in context of disease Prevalence
  2. Lower disease Prevalence results in higher NPV
    1. Test Sensitivity effect minimized at low Prevalence
    2. False Negatives decrease substantially
    3. Results in more reliable negative test

IV. Calculation

  1. NPV = (True negative) / (true and False Negatives)

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