Pharmacology Book

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NalmefeneAka: Revex

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  1. Indications
    1. Narcotic toxicity requiring frequent Naloxone dosing
  2. Precautions
    1. Do not use as first line agent for Narcotic toxicity
    2. Risk of severe Narcotic withdrawal
  3. Pharmacokinetics
    1. Long acting Opioid antagonist
    2. Duration: 4-8 hours
  4. Dosing
    1. Opioid overdose
      1. Initial: 0.5 mg per 70 kg person IV
      2. Later: 1 mg per 70 kg IV prn 5 min after initial dose
      3. Narcotic dependent: 0.1 mg per 70 kg test dose
    2. Post-operative Narcotic reversal
      1. Dose: 0.25 ug/kg IV q2-5 minutes
      2. Maximum: 1 ug/kg total dose

nalmefene (C0068377)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC038981
English6-desoxy-6-methylenenaltrexone, nalmefene, NALMEFENE PREPARATION
Spanishnalmefeno
Parent Conceptsmorphinan and derivatives (C0682978), Narcotic Antagonists (C0027410), Naltrexone (C0027360), [CN102] OPIOID ANTAGONIST ANALGESICS (C0973498), Drug allergen (C1320237)
SourcesAOD, MSH, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Revex (C0723050)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC038981
EnglishRevex
SourcesMSH, NCI, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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