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GlucosamineAka: Glucosamine Sulfate

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  1. See Also
    1. Osteoarthritis
    2. Chondroitin
  2. Pathophysiology
    1. Glucosamine is endogenous amino sugar, a precursor of glycosaminoglycans
    2. Glycosaminoglycans are present in joint structures such as Synovial Fluid
    3. Effects
      1. Stimulates chondrocyte metabolism
      2. May have anti-inflammatory effects at higher dose
  3. Source
    1. Marine exoskeleton or
    2. Synthetically derived
  4. Efficacy
    1. Appears more effective than Placebo at relieving pain
    2. Effect requires at least one month of therapy
    3. Less knee joint space narrowing with glucosamine over Placebo in 3 years
      1. Reginster (2001) Lancet 357:251
  5. Dosing
    1. Glucosamine 500 mg orally three times daily
  6. Adverse Effects
    1. Gastrointestinal upset
    2. Hemoglobin A1C and Serum Glucose are NOT impacted (contrary to initial reports)
      1. Scroggie (2003) Arch Intern Med 163:1587-90
    3. Glucosamine is safe in shellfish allergy (despite marine exoskeleton source)
      1. Gray (2004) J Allergy Clin Immunol 114:459
  7. Drug Interactions
    1. Warfarin (Coumadin)
      1. Warfarin's Anticoagulation effect is increased
  8. References
    1. Delafuente (2000) Rheum Dis Clin North Am 26:1
    2. McAlindon (2000) JAMA 283:1469
    3. Richy (2003) Arch Intern Med 163:1514

Glucosamine (C0017718)

Definition (CSP)amino sugar derivative of glucose, substituted at the 2 position, occurring in glycosaminoglycans and a variety of complex polysaccharides such as blood group substances.
ConceptsCarbohydrate (T118) , Pharmacologic Substance (T121)
MSHD005944
English2 Amino 2 Deoxyglucose, 2-Amino-2-Deoxyglucose, Glucosamine, GLUCOSAMINE PREPARATION, Glucosamine product, Glycosamine
Spanishglicosamina, glucosamina
Parent ConceptsHexosamines (C0019478), Unclassified Ingredients (C1372954), Unclassified Ingredient Preparations (C1377282), Amino Sugars (C0002531), Over the counter healthfood/herbal products (C0361218), Drug allergen (C1320237), Alternative medicine preparation (C1527378), Alternative medicine agent (C1626216)
SourcesCSP, MSH, MTH, NDFRT, RXNORM, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)



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