http://www.fpnotebook.com/

Glucosamine

Aka: Glucosamine, Glucosamine Sulfate

See Also
1. Osteoarthritis
2. Chondroitin
Pathophysiology
1. Glucosamine is endogenous amino sugar, a precursor of glycosaminoglycans
2. Glycosaminoglycans are present in joint structures such as Synovial Fluid
3. Effects
  1. Stimulates chondrocyte metabolism
  2. May have anti-inflammatory effects at higher dose
Source
1. Marine exoskeleton or
2. Synthetically derived
Efficacy
1. Appears more effective than Placebo at relieving pain
2. Effect requires at least one month of therapy
3. Less Knee Joint space narrowing with Glucosamine over Placebo in 3 years
  1. Reginster (2001) Lancet 357:251-6
Dosing
1. Glucosamine 500 mg orally three times daily
Adverse Effects
1. Gastrointestinal upset
2. Hemoglobin A1C and Serum Glucose are NOT impacted (contrary to initial reports)
  1. Scroggie (2003) Arch Intern Med 163:1587-90
3. Glucosamine is safe in shellfish allergy (despite marine exoskeleton source)
  1. Gray (2004) J Allergy Clin Immunol 114:459-60
Drug Interactions
1. Warfarin (Coumadin)
  1. Warfarin's Anticoagulation effect is increased
References

Medication Costs
Glucosamine-Chondroitin (on 2/9/2012 at DrugStore.com)
Glucosamine-Chondroitin 60 500-400mg Capsules Bottle	#1 for $18.99	($18.99/unit)
Glucosamine-Chondroitin 750-600mg Tablets	#30 for $14.99	($0.50/unit)
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Glucosamine (C0017718)
Definition (CSP)	amino sugar derivative of glucose, substituted at the 2 position, occurring in glycosaminoglycans and a variety of complex polysaccharides such as blood group substances.
Concepts	Carbohydrate (T118) , Pharmacologic Substance (T121)
MSH	D005944
SnomedCT	70237008, 408111007
English	Glucosamine, 2-Amino-2-Deoxyglucose, glucosamine, D-Glucose, 2-amino-2-deoxy-, glucosamine (medication), GLUCOSAMINE, Glucosamine [Chemical/Ingredient], glucosamines, glycosamine, glucosamine products, 2 Amino 2 Deoxyglucose, Glycosamine, Glucosamine (substance), Glucosamine (product), Glucosamine product
Swedish	Glukosamin
Czech	glukosamin
Finnish	Glukosamiini
Russian	GLIUKOZAMIN, ГЛЮКОЗАМИН
Polish	Glukozoamina
Japanese	キトサミン, グルコサミン
Spanish	glicosamina, glucosamina (sustancia), glucosamina, glucosamina (producto), Glucosamina
French	Chitosamine, Glucosamine, Glycosamine
German	Glucosamin, Glukosamin
Italian	Glucosamina
Portuguese	Glucosamina
Sources	Derived from the NIH UMLS (Unified Medical Language System)