Feverfew

Aka: Feverfew, Tanacetum parthenium

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II. Indications (Purported uses)

  1. Migraine Headache prevention

III. Efficacy

  1. Some studies support benefit for Migraine prevention
  2. No benefit in Rheumatoid Arthritis

IV. Mechanism

  1. Inhibits Prostaglandin synthesis
  2. Serotonin Antagonist
  3. Inhibits Platelet aggregation

V. Dosing

  1. Standard extract 125 mg (at least 0.2% parthenolide)

VI. Adverse Effects

  1. Bleeding Diathesis due to Platelet Dysfunction

VII. Contraindications

  1. Pregnancy
    1. Feverfew may induce Menstruation
  2. Concurrent Anticoagulant use or peri-operative
    1. Feverfew increases bleeding risk

VIII. References

  1. Shaughnessy (1997) Fam Practice Recert 19(10):53-6
  2. Zink (1998) Am Fam Physician 58(5): 1133-40 [PubMed]

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