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Organophosphate

Aka: Organophosphate, Organophosphate Poisoning, Carbamate
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  1. See Also
    1. Cholinergic Toxicity
    2. Pesticide
    3. Chemical Weapon
    4. Neurotoxin
  2. Organophosphates
    1. Management: See Organophosphate Poisoning Management
    2. Mechanism
      1. Irreversibly inhibits cholinesterase
      2. Results in Cholinergic Toxicity
    3. Pesticides
      1. Acephate (Orthene)
      2. Chlorphoxim (Baythion-C)
      3. Chlorpyrifos (Dursban, Lorsban)
      4. Diazinon
      5. Dimethoate (Cygon, Defend)
      6. Ethoprop (Mocap)
      7. Fenitrothion (Sumithion)
      8. Fenthion (Baytex)
      9. Malathion (Cythion)
      10. Naled (Dibrome)
      11. Terbufos (Counter)
    4. Other Organophosphate agents
      1. Triorthocresyl phosphate (TOCP)
        1. Used in hydraulic fluids, lubricants, plastics
        2. May contaminate foods and result in Neuropathy
  3. Carbamates
    1. Mechanism
      1. Reversible cholinesterase inhibition
      2. Results in Cholinergic Toxicity
        1. Less severe toxicity than with Organophosphates
    2. Management
      1. Similar to Organophosphate Poisoning Management
      2. 2-PAMCl not indicated unless mixed exposure
    3. Pesticides
      1. Carbaryl (Sevin)
      2. Primicarb (Aphox, Rapid)
      3. Propoxur (Baygon)
      4. Timethacarb (Landrin)

Carbamates (C0006948)

Definition (MSH) Salts or esters of carbamic acid, H2NC(=O)OH, or of N-substituted carbamic acids: R2NC(=O)OR', (R' = hydrocarbyl or a cation). The esters are often called URETHANE or urethan, a usage that is strictly correct only for the ethyl esters. (From IUPAC [Internet]. International Union Of Pure And Applied Chemistry; c1995 [updated 2004 Jan 9; cited 2004 May 3]. Available from http://www.chem.qmul.ac.uk/iupac/class/oneN.html#35/).
Definition (CSP) carbamic acid, its salts or esters; contains the general formula NH2-COO-.
Concepts Organic Chemical (T109)
MSH D002219
SnomedCT 79522001, 406748003
English carbamate, Carbamates, NOS, carbamates, Carbamates, Carbamates [Chemical/Ingredient], Carbamate, Carbamate (substance)
Swedish Karbamater
Czech karbamáty, pentakain
Finnish Karbamaatit
Russian KARBAMATY, КАРБАМАТЫ
Croatian Not Translated[Carbamates]
Polish Karbaminiany
Spanish carbamatos, carbamato (sustancia), carbamato, Carbamatos
French Carbamates
German Carbamate
Italian Carbammati
Portuguese Carbamatos
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Phosphoric Acid Esters (C0031701)

Definition (NCI) A form of phosphoric acid, which contains phosphorus. In the body, phosphates are found in the bones and teeth. Phosphates may be used to treat a high level of calcium in the blood. Adding or removing phosphate chemical groups may affect the way proteins act in the body.
Definition (NCI) An ester of phosphoric acid, which contains phosphorus. Organic phosphates play important roles in biochemistry and biogeochemistry or ecology.
Definition (MSH) Organic esters of phosphoric acid.
Definition (CSP) organic esters of phosphoric acid.
Concepts Organophosphorus Compound (T115)
MSH D010755
SnomedCT 50352000, 301785006
English Acid Esters, Phosphoric, Esters, Phosphoric Acid, Organic Phosphates, Phosphates, Organic, phosphoric ester, Organic phosphate, NOS, Organophosphate, NOS, PHOSPHATES ORG, ORGANOPHOSPHATE, Phosphoric Acid Esters [Chemical/Ingredient], organophosphate, organic phosphates, organophosphates, organic phosphate, Organic Phosphate, phosphate, Phosphoric Acid Esters, Organic phosphate, Organophosphate, Phosphoric acid ester, Phosphoric acid ester (substance)
Swedish Fosforsyraestrar
Czech organofosfáty, estery kyseliny fosforečné
Finnish Fosforihappoesterit
Italian Fosfati organici, Esteri dell'acido fosforico
Russian FOSFATY ORGANICHESKIE, ORGANICHESKIE FOSFATY, FOSFORNOI KISLOTY EFIRY, ФОСФАТЫ ОРГАНИЧЕСКИЕ, ФОСФОРНОЙ КИСЛОТЫ ЭФИРЫ, ОРГАНИЧЕСКИЕ ФОСФАТЫ
Japanese 有機リン酸塩, 有機リン酸, りん酸エステル, 有機りん酸塩, 燐酸エステル, リン酸エステル
Polish Estry kwasu fosforowego
Spanish éster de ácido fosfórico (sustancia), éster de ácido fosfórico, Esteres del Acido Fosforico, Fosfatos Organicos, Fosfatos Orgánicos, Ésteres del Ácido Fosfórico
French Esters acide phosphorique
German Phosphate, organische, Phosphorsäureester
Portuguese Fosfatos Orgânicos, Ésteres do Ácido Fosfórico
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Organophosphate poisoning (C0700359)

Concepts Injury or Poisoning (T037)
SnomedCT 71597002, 8260003, 88041008
English ORGANIC PHOSPHATE POISONING, Organophosphate poisoning, Orgnphos insectcd caus tox eff, poisoning by organophosphate (diagnosis), poisoning by organophosphate, ORGANOPHOSPHATE POISONING, organophosphate poisoning, organophosphate poison, organophosphate toxicity, phosphate organic poisoning, organic phosphate poisoning, organophosphates poisoning, Organic phosphate poisoning, Organophosphate insecticide poisoning, Organophosphate toxicity, Organophosphate insecticide causing toxic effect, Organophosphate poisoning (disorder)
Spanish intoxicación por fosfato orgánico, intoxicación por insecticida organofosforado, intoxicación por organofosforados (trastorno), intoxicación por organofosforados
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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