Neurology Book

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Muscarinic Agonist

Aka: Muscarinic Agonist, Pilocarpine, Salagen, Cevimeline, Evoxac
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  1. Mechanism
    1. Cholinergic agonist acting at muscarinic receptors
  2. Indications
    1. Sjogren's SyndromeDry Eyes (and possibly Dry Mouth) refractory to general measures
  3. Contraindications
    1. Angle closure Glaucoma
    2. Uncontrolled Asthma
  4. Adverse effects
    1. Diaphoresis
    2. Decreased night vision
    3. Nonselective agents (Pilocarpine) may have cardiopulmonary effects
  5. Preparation: Pilocarpine (Salagen)
    1. Nonselective (may have cardiac or lung effects)
    2. Dose: 5 mg orally twice daily
  6. Preparation: Cevimeline (Evoxac)
    1. Selective for exocrine glands
    2. Dose: 30 mg orally three times daily
  7. References
    1. Fife (2002) Arch Intern Med 162(11): 1293-300
    2. Ono (2004) Am J Ophthalmol 138(1): 6-17
    3. Tsifetaki (2003) Ann Rheum Dis 62(12): 1204-7
    4. Wu (2006) J Formos Med Assoc 105(10): 796-803
Medication Costs
PILOCARPINE (on 2/10/2012 at Target.com)
PILOCARPINE 1% OphthalmicSolution #30 for $4.00 ($0.13/unit)
PILOCARPINE 2% OphthalmicSolution #30 for $4.00 ($0.13/unit)
Pilocarpine HCl (on 2/9/2012 at DrugStore.com)
Pilocarpine HCl 5mg Tablets #90 for $99.99 ($1.11/unit)
Pilocarpine HCl 7.5mg Tablets #30 for $55.99 ($1.87/unit)
Pilocarpine HCl 2% Solution 15ml Bottle #1 for $27.99 ($27.99/unit)
Pilocarpine HCl 1% Solution 15ml Bottle #1 for $53.99 ($53.99/unit)
Pilocarpine HCl 4% Solution 15ml Bottle #1 for $56.76 ($56.76/unit)
Salagen (on 2/9/2012 at DrugStore.com)
Salagen 7.5mg Tablets #100 for $247.00 ($2.47/unit)
Salagen 5mg Tablets #90 for $173.98 ($1.93/unit)
Evoxac (on 2/9/2012 at DrugStore.com)
Evoxac 30mg Capsules #30 for $95.99 ($3.20/unit)
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

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