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Midodrine
Aka: Midodrine- Indications
- Mechanism
- Alpha agonist: constricts arterioles and veins
- Increases peripheral resistance
- Efficacy
- Study: n=162, PCT
- Significantly improved standing BP and symptoms
- Reference
- Study: n=162, PCT
- Adverse Effects
- Pilomotor reactions
- Urinary urgency and retention
- Supine Hypertension
- Dosing
- Dose: 10 mg PO tid
| Medication Costs | ||
|---|---|---|
| Midodrine HCl (on 2/9/2012 at DrugStore.com) | ||
| Midodrine HCl 10mg Tablets | #100 for $291.01 | ($2.91/unit) |
| Midodrine HCl 5mg Tablets | #100 for $199.99 | ($2.00/unit) |
| FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. | ||
Midodrine (C0026078) |
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|---|---|
| Definition (MSH) | An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION. |
| Definition (NCI) | A direct-acting prodrug and sympathomimetic agent with antihypotensive properties. Midodrine is converted to its active metabolite, desglymidodrine by deglycination reaction. Desglymidodrine selectively binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to an elevation of blood pressure. Desglymidodrine diffuses poorly across the blood-brain barrier, and is therefore not associated with effects on the central nervous system (CNS). |
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D008879 |
| SnomedCT | 108539003, 372504000 |
| English | Midodrin, Midodrine, Acetamide, 2-amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)-, MIDODRINE, midodrine, Midodrine [Chemical/Ingredient], midodrin, Midodrine (product), Midodrine (substance) |
| Swedish | Midodrin |
| Czech | midodrin |
| Finnish | Midodriini |
| Russian | MIDODRIN, МИДОДРИН |
| Japanese | ミドドリン |
| Polish | Midodrin |
| Spanish | midodrina (producto), midodrina (sustancia), midodrina, Midodrina |
| French | Midodrine |
| German | Midrodin |
| Italian | Midodrina |
| Portuguese | Midodrina |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |