Pulmonology Book

http://www.fpnotebook.com/

Multiple Drug Resistant Tuberculosis Treatment

Aka: Multiple Drug Resistant Tuberculosis Treatment, Multiple Drug Resistant Tb Treatment
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  1. See Also
    1. Tuberculosis
    2. Latent Tuberculosis Treatment
    3. Active Tuberculosis Treatment
      1. Susceptible Tuberculosis Treatment
      2. Possibly Resistant Tuberculosis Treatment
  2. Indications
    1. Resistant to at least Isoniazid and Rifampin
  3. General
    1. Treat with 3 or more drugs to which Tb is sensitive
    2. Consider starting 5-7 drugs before susceptibility known
      1. Indicated for high risk or previously treated Tb
    3. Continue Rx for 12-24 months after Cultures negative
    4. Parenteral drugs may increase rate of cure
    5. Lung resection with medications may increase cure rate
  4. Management
    1. Standard Main Drugs
      1. Isoniazid (INH)
      2. Rifampin
      3. Ethambutol
      4. Pyrazinamide
    2. Secondary additional drugs
      1. Aminoglycoside or Capreomycin
      2. Ciprofloxacin or Ofloxacin
      3. Cycloserine, Ethionamide, or para-aminosalicylic acid

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