Pulmonology Book

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Ipratropium

Aka: Ipratropium, Ipratropium Bromide, Atrovent, Short-acting Anticholinergic Bronchodilator, Combivent, Combivent Respimat
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  1. Indications
    1. Chronic Obstructive Pulmonary Disease (COPD)
    2. Asthma
  2. Mechanism
    1. Short-acting Anticholinergic Bronchodilator
  3. Preparations: Ipratropium Bromide
    1. Atrovent MDI: 2-3 puffs three to four times daily
    2. Atrovent Nebulization: 1 ampule in nebulization solution every 6 hours prn
  4. Preparations: Combination Ipratropium with Albuterol (Combivent)
    1. Combivent (older CFC version)
      1. Will be phased out in 2013 due to CFC
      2. Dose: 2 puffs up to every 6 hours
      3. Contraindicated in soybean or peanut allergy
    2. Combivent Respimat
      1. Dose: 1 puff every 6 hours
      2. Does not carry the Food Allergy related contraindications of the older Combivent
  5. Adverse Effects
    1. Serious adverse effects
      1. Anaphylaxis, Angioedema or other Hypersensitivity Reaction
      2. Paradoxical bronchospasm or Laryngospasm
      3. Exacerbation of Glaucoma
    2. Common adverse effects
      1. Cough
      2. Dry Mouth or oral irritation
      3. Gastrointestinal upset such as Nausea
      4. Urticaria or other rash
      5. Headache
      6. Nervous sensation
Medication Costs
IPRATROPIUM NEB (on 2/10/2012 at Target.com)
IPRATROPIUM NEB 0.2 MG/ML* Solution #30 for $4.00 ($0.13/unit)
Ipratropium Bromide (on 2/9/2012 at DrugStore.com)
Ipratropium Bromide 0.03% Solution 30ml Inhaler #1 for $37.99 ($37.99/unit)
Ipratropium Bromide 0.02% Solution 2.5ml Plastic Container #25 for $14.99 ($0.60/unit)
Ipratropium Bromide 0.06% Solution #15 for $34.99 ($2.33/unit)
Ipratropium-Albuterol (on 2/9/2012 at DrugStore.com)
Ipratropium-Albuterol 0.5-2.5 (3)mg/3ml Solution 3ml Plastic Container #30 for $39.99 ($1.33/unit)
Atrovent (on 2/9/2012 at DrugStore.com)
Atrovent 0.03% Solution 30ml Nasal Spray #1 for $100.99 ($100.99/unit)
Atrovent 0.06% Solution 15ml Nasal Spray #1 for $91.99 ($91.99/unit)
Combivent (on 2/9/2012 at DrugStore.com)
Combivent 18-103mcg/act Aerosol 14.7gm Inhaler #1 for $238.33 ($238.33/unit)
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Ipratropium (C0027235)

Definition (NCI) A synthetic derivative of the alkaloid atropine with anticholinergic properties. Ipratropium antagonizes the actions of acetylcholine at parasympathetic postganglionic effector cell junctions. When inhaled, ipratropium binds competitively to cholinergic receptors in the bronchial smooth muscle thereby blocking the bronchoconstrictor actions of the acetylcholine (Ach) mediated vagal impulses. Inhibition of the vagal tone leads to dilation of the large central airways resulting in bronchodilation.
Definition (MSH) A muscarinic antagonist structurally related to ATROPINE but often considered safer and more effective for inhalation use. It is used for various bronchial disorders, in rhinitis, and as an antiarrhythmic.
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D009241
SnomedCT 349952008, 108624006, 372518007
English Ipratropium, N Isopropylatropine, N-Isopropylatropine, (endo,syn)-(+-)-3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2.1)octane, 8-Azoniabicyclo(3.2.1)octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, (endo,syn)-(+-)-, ISOPROPYLATROPINE N, ipratropium, (3-endo,8-syn)-3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2.1)octane, Ipratropium [Chemical/Ingredient], Ipratropium (product), Ipratropium (substance), IPRATROPIUM
Swedish Ipratropium
Czech ipratropium, ipratropiumbromid, N-isopropylatropin
Spanish Ipratropium, ipratropio (producto), ipratropio (sustancia), ipratropio, Ipratropio, N-Isopropilatropina
Finnish Ipratropium
Russian IPRATROPII, N-IZOPROPILATROPIN, N-ИЗОПРОПИЛАТРОПИН, ИПРАТРОПИЙ
Japanese イプラトロピウム, N-イソプロピルアトロピン, 臭化イプラトロピウム, イソプロピルアトロピン
German ISOPROPYLATROPIN N, Ipratropium, N-Isopropylatropin
French Ipratropium
Polish Ipratropium, N-izopropyloatropina, Bromek ipratropium
Italian Ipratropio
Portuguese Ipratropio, N-Isopropilatropina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Atrovent (C0591130)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D009241
English atrovent, Atrovent
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Combivent (C0591282)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH C116388
English Combivent, combivents, combivent
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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