Pulmonology Book

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Pulmonary Embolism Pretest Probability

Aka: Pulmonary Embolism Pretest Probability, Wells Clinical Prediction Rule for PE
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  1. See Also
    1. Pulmonary Embolism
  2. Criteria
    1. PE more likely than alternatives: 3.0 points
    2. Deep Vein Thrombosis (DVT) suspected: 3.0 points
    3. Tachycardia (pulse >100 beats per minute): 1.5 points
    4. Surgery or immobilization in last 4 weeks: 1.5 points
    5. Prior DVT or Pulmonary Embolism: 1.5 points
    6. Hemoptysis: 1.0 points
    7. Active malignancy: 1.0 points
  3. Interpretation
    1. Score 0-2 points: Low PE Probability (3.6% risk)
      1. Positive Likelihood Ratio: 0.1
      2. Negative Likelihood Ratio: 7.6
    2. Score 3-6 points: Moderate PE Probability (20.5% risk)
      1. Positive Likelihood Ratio: 1.3
      2. Negative Likelihood Ratio: 0.7
    3. Score >6 points: High PE Probability (66.7% risk)
      1. Positive Likelihood Ratio: 6.8
      2. Negative Likelihood Ratio: 1.8
  4. Interpretation: Simplified
    1. Score 4 or less: Unlikely
    2. Score >4: Likely
    3. D-Dimer negative with "unlikely" score safely excludes Pulmonary Embolism
  5. References
    1. Tamariz (2004) Am J Med 117(9): 676-84
    2. Wells (2000) Thromb Haemost 83:416-20
    3. Wells (2001) Ann Intern Med 135(2): 98-107

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