III. Indications
- Respiratory tract infections
- Acute Sinusitis
- Otitis Media
- Community Acquired Pneumonia (esp. Cefuroxime and Cefprozil)
- Urinary Tract Infection (esp. Cefuroxime and Cefprozil)
- Skin and Soft Tissue Infection (esp. Cefuroxime and Cefprozil)
IV. Preparations
- Loracarbef (Lorabid)
- Adult: 200 to 400 mg po bid
- Child
- Otitis Media: 30 mg/kg/day divided bid
- Other infections: 15 mg/kg/day divided bid
- Directions
- Take more than 1 hour before or 2 hours after food
- Cefprozil (Cefzil)
- Adult: 250 to 500 mg orally divided daily to twice daily
- Child
- Otitis Media: 15 mg/kg/dose orally twice daily
- Pharyngitis: 7.5 mg/kg/dose orally twice daily for 10 days
- Cefuroxime (Ceftin, Zinacef)
- Adult
- Parenteral: 750 to 1500 mg IM or IV every 8 hours
- Oral: 250 to 500 mg orally twice daily
- Child
- Parenteral: 50-100 mg/kg/day IV divided every 6-8 hours
- Oral: 20-30 mg/kg/day orally divided twice daily
- Reported to have unpleasant taste
- Directions
- Take with food
- Adult
- Cefaclor (Ceclor)
- Listed for historical reference only
- Risk of significant serum-sickness type reaction
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Related Studies
| cefuroxime (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| CEFUROXIME AXETIL 250 MG TAB | Generic | $0.84 each |
| CEFUROXIME AXETIL 500 MG TAB | Generic | $1.26 each |
| cefprozil (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| CEFPROZIL 125 MG/5 ML SUSP | Generic | $0.24 per ml |
| CEFPROZIL 250 MG TABLET | Generic | $1.01 each |
| CEFPROZIL 250 MG/5 ML SUSP | Generic | $0.45 per ml |
| CEFPROZIL 500 MG TABLET | Generic | $1.35 each |
| ceftin (on 1/1/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| CEFTIN 125 MG/5 ML ORAL SUSP | $1.43 per ml | |
| CEFTIN 250 MG/5 ML ORAL SUSP | $2.37 per ml | |
Ontology: Cefuroxime (C0007562)
| Definition (NCI) | A semisynthetic, broad-spectrum, beta-lactamase-resistant, second-generation cephalosporin with antibacterial activity. Cefuroxime binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. |
| Definition (MSH) | Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS. |
| Concepts | Antibiotic (T195) , Organic Chemical (T109) |
| MSH | D002444 |
| SnomedCT | 372833007, 73986003 |
| LNC | LP32648-5, MTHU027952 |
| English | Cefuroxime, Cephuroxime, 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-7-((2-furanyl(methoxyimino)acetyl)amino)-8-oxo-, (6R-(6alpha,7beta(Z)))-, cefuroxime (medication), Cefuroxime [Chemical/Ingredient], CEFUROXIME, cephuroxime, cefuroxime, Cefuroxime (product), Cefuroxime (substance) |
| Swedish | Cefuroxim |
| Czech | cefuroxim |
| Finnish | Kefuroksiimi |
| Russian | TSEFUROKSIM, ЦЕФУРОКСИМ |
| Japanese | セフロキシム |
| Croatian | CEFUROKSIM |
| Polish | Cefuroksym |
| Spanish | cefuroxima (producto), cefuroxima (sustancia), cefuroxima, Cefuroxima |
| French | Céfuroxime |
| German | Cefuroxim |
| Italian | Cefuroxima |
| Portuguese | Cefuroxima |
Ontology: cefprozil (C0053882)
| Definition (NCI) | A semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefprozil's effect is dependent on its binding to penicillin-binding proteins (PBPs) located in the bacterial cytoplasmic membrane. Binding results in the inhibition of the transpeptidase enzymes, thereby preventing cross-linking of the pentaglycine bridge with the fourth residue of the pentapeptide and interrupting consequent synthesis of peptidoglycan chains. As a result, cefprozil inhibits bacterial septum and cell wall synthesis formation. |
| Concepts | Antibiotic (T195) , Organic Chemical (T109) |
| MSH | C052018 |
| SnomedCT | 387538005, 96054007 |
| LNC | LP15219-6, MTHU001907 |
| English | cefprozil, CEFPROZIL, cefprozil (medication), 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2R)-amino(4-hydroxyphenyl)acetyl)amino)-8-oxo-3-(1-propenyl)-, (6R,7R)-, cefprozil [Chemical/Ingredient], Cefprozil, Cefprozil (product), Cefprozil (substance) |
| Spanish | cefprozilo (producto), cefprozilo, cefprozilo (sustancia), cefprozil, cefprozil (producto), cefprozil (sustancia) |
Ontology: loracarbef (C0065295)
| Definition (NCI) | A semi-synthetic, broad-spectrum, beta-lactamase resistant, second-generation cephalosporin antibiotic derived from cephasporium. The bactericidal activity of loracarbef results from the inhibition of bacterial cell wall synthesis through interference with the cross-linking of peptidoglycan units. This results in a reduction of cell wall stability and causes cell lysis. Loracarbef is more active against a variety of gram-negative organisms but less active against gram-positive pathogens compared to first-generation agents. |
| Concepts | Antibiotic (T195) , Organic Chemical (T109) |
| MSH | C054920 |
| SnomedCT | 96061006, 370362008 |
| LNC | LP15927-4, MTHU008099 |
| English | 1-Azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((aminophenylacetyl)amino)-3-chloro-8-oxo-, (6R-(6alpha,7beta(R*)))-, loracarbef, (6R, 7S)-7-[(R)-2-Amino-2-phenylacetamido]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid, Monohydrate, loracarbef (medication), loracarbef [Chemical/Ingredient], Carbacefaclor, Loracarbef, Loracarbef (substance), Loracarbef product (product), Loracarbef product, LORACARBEF |
| Spanish | loracarbef, producto con loracarbef (producto), loracarbef (producto), producto con loracarbef, carbacefaclor (sustancia), carbacefaclor |
Ontology: Ceftin (C0719197)
| Concepts | Antibiotic (T195) , Organic Chemical (T109) |
| MSH | C040738 |
| English | Ceftin, ceftin |
Ontology: Lorabid (C0721422)
| Concepts | Antibiotic (T195) , Organic Chemical (T109) |
| MSH | C054920 |
| English | lorabid, Lilly Brand of Loracarbef Monohydrate, Monarch Brand of Loracarbef Monohydrate, Lorabid |
Ontology: Cefzil (C0728743)
| Concepts | Antibiotic (T195) , Organic Chemical (T109) |
| MSH | C052018 |
| English | Cefzil, cefzil, Bristol-Myers Squibb brand of cefprozil |
