Typhoid Vaccine

Aka: Typhoid Vaccine, Typhoid Conjugate Vaccine, Live Oral Typhoid Vaccine, Ty21a, VIVOTIF, TYPHIM Vi Capsular Polysaccharide Vaccine

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II. Indications: Travel to endemic areas

  1. Africa
    1. Egypt
  2. Asia
    1. Philippines
    2. India
    3. Pakistan
    4. Korea
  3. Central America
    1. Haiti
  4. South America
    1. Peru
    2. Chile

III. Preparations

  1. Subcutaneous Typhoid Inactivated Vaccine
    1. Dose 1: Typhoid 0.5 ml SC on Day 0
    2. Dose 2: Typhoid 0.5 ml SC on Day 30
    3. Booster: Typhoid 0.1 ml ID every 3 years
  2. Live Oral Typhoid Vaccine (Ty21a, VIVOTIF)
    1. Initial
      1. Capsule: One capsule orally every other day for 4 doses
      2. Liquid: Three doses
    2. Booster: repeat every 5 years
  3. TYPHIM Vi Capsular Polysaccharide Vaccine
    1. Single Injection

IV. Efficacy

  1. Estimated to be 70% effective
  2. Live Oral Typhoid Vaccine has better immunogenicity

V. Precautions

  1. Subcutaneous Typhoid Vaccine
    1. Safe in HIV Infection
    2. Avoid in Pregnancy
  2. Typhoid live (oral Ty21a)
    1. Reportedly safe in HIV Infection

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