II. Background
- Vaccine no longer available in U.S.
III. Indication: Prevention of Lyme Disease in high risk areas
- Ages 15 to 70 years old
- Live, work or recreate in high risk areas
- Frequent or prolonged Deer Tick exposure
IV. Mechanism
- Recombinant outer surface protein Borrelia Burgdorferi
- Antibodies responding to Vaccine form
- Destroy Spirochetes in tick gut prior to transmission
V. Efficacy
- Studied in 20 month, double blind trial (n=11,000)
- After 2 doses: 49% effective
- After 3 doses: 76% effective
- Prevents 100% of asymptomatic infections
- References
VI. Adverse Effects
- Soreness at injection site
- Flu-like illness with fever and chills
- Onset days 1-2 after Immunization
- Duration 2-3 days
- Risk of autoimmune Arthritis
VII. Dosing
- Three doses: 0, 1, and 12 months Intramuscular
- Third dose can be given at 2 or 6 months also
- Consider scheduling first dose in March
- April starts tick season
- Pharmacist cost: $61.25 per dose