Hematology and Oncology Book

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Streptokinase

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  1. See Also
    1. Thrombolytic
  2. Dose
    1. Streptokinase 1.5 million units over 60 minutes
    2. Premedication
      1. Hydrocortisone 100 mg IV
      2. Diphenhydramine 25 mg IV
  3. Benefits
    1. Cost: $200
    2. Lasts longer than T-PA (duration ~12 hours)
    3. Less bleeding risk
      1. Probably less risk than T-PA in over age 75

Streptokinase (C0038418)

Definition (MSH)Streptococcal fibrinolysin . An enzyme produced by hemolytic streptococci. It hydrolyzes amide linkages and serves as an activator of plasminogen. It is used in thrombolytic therapy and is used also in mixtures with streptodornase (STREPTODORNASE AND STREPTOKINASE). EC 3.4.-.
Definition (CSP)nonEC; enzyme elaborated by hemolytic streptococci which produces fibrinolysis by activating plasminogen to plasmin; it is used as a thrombolytic agent.
ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121) , Enzyme (T126)
MSHD013300
EnglishSK - Streptokinase, Streptokinase, Streptokinase agent, Streptokinase preparation
Spanishestreptocinasa, estreptokinasa, estreptoquinasa, preparado de estreptoquinasa
Parent ConceptsSerine Protease (C0036734), Fibrinolytic Agents (C0016018), Peptide Hydrolases (C0030940), Bacterial exotoxin (C0314768), Endopeptidases (C0030946), Plasminogen Activator (C0032144), Streptokinase (C0038418), Plasminogen activator agent (C1636198)
SourcesAOD, CSP, LCH, LNC, MSH, NDFRT, RXNORM, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)



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