Hematology and Oncology Book

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AzathioprineAka: Imuran

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  1. Indications
    1. Renal homograft maintenance
    2. Myasthenia Gravis
    3. Systemic Lupus Erythematosus (Lupus Nephritis)
    4. Acute Glomerulonephritis
  2. Pharmacology
    1. Imidazolyl derivative of mercaptopurine
      1. Metabolized to mercaptopurine as active ingredient
    2. Structural Analogue Chemotherapy (purine)
  3. Adverse effects (similar to mercaptopurine)
    1. Bone Marrow suppression
      1. Leukopenia
      2. Anemia
      3. Thrombocytopenia
    2. Skin rash
    3. Drug Fever
    4. Nausea, Vomiting or Diarrhea
    5. Hepatic dysfunction
  4. Monitoring
    1. Complete Blood Count
    2. Liver Function Tests

Azathioprine (C0004482)

Definition (MSH)An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
Definition (CSP)immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis; possible carcinogen.
Definition (NCI)A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD001379
EnglishAZA, Azathioprine, Azathioprine - chemical, AZATHIOPRINE PREPARATION, Azothioprine, AZT - Azathioprine, AZTP
Spanishazatioprina
Parent Concepts6-Mercaptopurine (C0000618), Immunosuppressive Agents (C0021081), Thionucleosides (C0039922), Purine antagonist (C0280038), Inosine 5'-Phosphate Dehydrogenase Inhibitor (C1512791), Antirheumatic Agents (C0003191), Azathioprine (C0004482), Carcinogens (C0007090), Ambiguous concept (C1274012), Duplicate concept (C1274013), Immune Suppressants (Non-TNF Inhibitors) (C1579325)
SourcesCSP, LNC, MSH, MTH, MTHSPL, NCI, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Imuran (C0699279)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD001379
EnglishImmuran, Imuran
SourcesMSH, NCI, PDQ, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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