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Prothrombin TimeAka: ProTime, Pro-Time, PT

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  1. Normal
    1. Range: 10-12 sec
  2. Increased
    1. Liver disease
    2. Heparin, Warfarin
    3. Clotting Factor deficiency
      1. Factor I Deficiency
      2. Factor II Deficiency
      3. Factor V Deficiency
      4. Factor VII Deficiency
      5. Factor X Deficiency
    4. Disseminated Intravascular Coagulation (DIC)
    5. Vitamin K Deficiency
    6. Afibrinogenemia
    7. Dysfibrinogenemia
    8. Medications
      1. Salicylate or Aspirin
      2. Chloral Hydrate
      3. Diphenylhydantoin
      4. Estrogens
      5. Antacids
      6. Phenylbutazone
      7. Quinidine
      8. Antibiotics
      9. Allopurinol
      10. Anabolic Steroids
  3. Decreased
    1. Vitamin K supplementation
    2. Thrombophlebitis
    3. Medications
      1. Glutethimide
      2. Estrogens
      3. Griseofulvin
      4. Diphenhydramine

Prothrombin time assay (C0033707)

Definition (MSH)Clotting time of PLASMA recalcified in the presence of excess TISSUE THROMBOPLASTIN. Factors measured are FIBRINOGEN; PROTHROMBIN; FACTOR V; FACTOR VII; and FACTOR X. It is used for monitoring anticoagulant therapy with COUMARINS.
Definition (CSP)clotting time of plasma recalcified in the presence of excess tissue thromboplastin; used for monitoring anticoagulant therapy with coumarins.
Definition (NCI)A measurement of the clotting time of plasma recalcified in the presence of excess tissue thromboplastin; it is a measure of the extrinsic pathway of coagulation. It is used to determine the clotting tendency of blood, in the measure of warfarin dosage, liver damage and vitamin K status. Factors measured are fibrinogen, prothrombin, and factors V, VII, and X.
Definition (NCI)A blood clotting measurement that evaluates the extrinsic pathway of coagulation and is expressed in units of time or percent activity.
ConceptsLaboratory Procedure (T059)
MSHD011517
EnglishOne stage prothrombin time, Prothrombin Time, Prothrombin time assay, Prothrombin Time Test, Prothrombin Times, Protime, PT, PT - Prothrombin time, PT assay, PTT - Prothrombin time, Quick one stage prothrombin time
Spanishtiempo de protrombina, tiempo de protrombina rapido en un paso, tiempo de PT
Parent ConceptsBlood coagulation tests (C0005790), Blood Physiologic Phenomena (C1257981), Extrinsic coagulation pathway factor measurement (C0427590), Ambiguous concept (C1274012)
SourcesAOD, CSP, MSH, MTH, NCI, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)


Point in time (C1442880)

ConceptsTemporal Concept (T079)
EnglishPoint in time, Pt
SourcesLNC, MTH
Derived from the NIH UMLS (Unified Medical Language System)



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