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Mean Corpuscular VolumeAka: MCV Cutoffs for Microcytic Anemia, MCV, Mentzer Index

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  1. Findings: Normal (Units in femtoliters = 10^-15 liters)
    1. General
      1. MCV cutoffs vary from age to age
      2. MCV cutoffs also vary per reference
    2. MCV Normal Range
      1. Newborn: 95 to 121 fl
      2. Ages 6 months to 2 years: 70 to 86 fl
      3. Ages 12 to 18 years
        1. Boys: 78 - 98
        2. Girls: 78 - 102
      4. Age over 18 years: 78 to 98 fl
    3. MCV Cutoffs for Microcytic Anemia
      1. Age 1-2 years: <77 fl (CDC)
      2. Age 3-5 years: <79 fl (CDC)
      3. Age 6-11 years: <80 fl (CDC)
      4. Age 12-15 years: <82 fl (CDC)
      5. Age >15 years: <85 fl (CDC)
        1. Recommended adult microcytic MCV cutoff varies
        2. Some sources advocate MCV <78 and others <82
  2. Calculations
    1. MCV = 10 x (Hematocrit / Red Blood Cell Count)
    2. Mentzer Index = MCV / RBC Count
      1. Ratio <13: Thalassemia
      2. Ratio >13: Iron Deficiency Anemia, Hemoglobinopathy
  3. Causes: Increased MCV (See Macrocytic Anemia)
    1. Vitamin B12 Deficiency
    2. Folic Acid deficiency
    3. Alcohol Abuse
    4. Liver disease
    5. Marrow aplasia
    6. Myelofibrosis
    7. Reticulocytosis
    8. Hypothyroidism
  4. Causes: Decreased MCV (See Microcytic Anemia)
    1. Iron Deficiency Anemia
    2. Thalassemia
    3. Hemoglobinopathy
    4. Anemia of Chronic Disease
    5. Sideroblastic Anemia
    6. Chronic Renal Failure
    7. Lead Poisoning
  5. References
    1. Dallman in Hallberg (1996) Iron Nutrition, p. 65-74
    2. (1998) MMWR Morb Mortal Wkly Rep 47:1
      1. http://www.cdc.gov/mmwr/pdf/rr/rr4703.pdf

Mean Corpuscular Volume (result) (C0524587)

Definition (MSH)MCV equals HEMATOCRIT divided by ERYTHROCYTE COUNT.
ConceptsLaboratory or Test Result (T034)
MSHD004909
EnglishErythrocyte mean corpuscular volume, MCV, Mean Cell Volume, Mean cell volume - finding, Mean Cell Volumes, Mean Corpuscular Volume, Mean Corpuscular Volumes
SpanishMCV, VCM, volumen corpuscular eritrocitico medio, volumen corpuscular medio - hallazgo, volumen corpuscular medio de los eritrocitos, volumen corpuscular medio de los globulos rojos
Parent ConceptsRed blood cell finding (C0427454), Duplicate concept (C1274013)
SourcesAOD, LNC, MSH, MTH, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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