Hematology and Oncology Book

Acute Phase Reactant

Anemia

Bone Marrow Disorders

Cancer

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Complete Blood Count

Hemolytic Disorders

Lymphatic Disorders

Miscellaneous

Platelet Disorders

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Lymphocyte CountAka: Lymphocyte, B-Lymphocyte, T-Lymphocyte, Natural Killer Cell, Lymphocytosis

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  1. Characteristics
    1. Function: Primary source of viral defense and Antibody
      1. Lymphocyte Sub-Classes
        1. B-Lymphocytes
          1. Differentiate into plasma cells
          2. Plasma cells release specific antibodies
        2. T-Lymphocytes
          1. Response to viral infection, cancer, foreign cell
        3. Natural Killer Cells (NK Cells)
          1. Attack cancer cells and cells infected with virus
    2. Morphology on Blood Smear
      1. Mononuclear Leukocytes (same class as Monocytes)
      2. Small cells with minimal cytoplasm
  2. Normal
    1. Percentage Lymphocytes: 15-40% of White Blood Cells
    2. Total lymphocytes: 800-2600/mm�
    3. Total T Lymphocytes: 800-2200/mm�
      1. T helper Cells: >400/mm�
      2. T suppressor Cells: 250-750/mm�
      3. Helper Cell to Suppressor Cell ratio: >0.9
      4. CD2 Percentage of lymphocytes: 65-85%
      5. CD4 Percentage of lymphocytes: 45-75%
  3. Increased (Lymphocytosis)
    1. Increased Absolute Lymphocyte Count (>4500/mm3)
      1. Non-activated Lymphocytes
        1. Influenza
        2. Pertussis
        3. Tuberculosis
        4. Mumps
        5. Varicella
        6. Herpes Simplex Virus
        7. Rubeola
        8. Brucellosis
        9. Chronic Lymphocytic Leukemia
        10. Acute Lymphoblastic Leukemia
      2. Activated Lymphocytes (Atypical lymphocytes)
        1. Cytomegalovirus Infection
        2. Infectious Mononucleosis
        3. Infectious Hepatitis
        4. Toxoplasmosis
        5. Post-transfusion
        6. Medication
          1. Mephenytoin
          2. Dilantin
          3. Para-aminosalicylic acid
    2. Increased Relative Lymphocyte Count
      1. Normal finding in children under age 2 years
      2. Acute stage of viral infection
      3. Connective tissue disease
      4. Hyperthyroidism
      5. Addison's Disease
      6. Splenomegaly
  4. Decreased
    1. AIDS
    2. Bone Marrow suppression
    3. Aplastic Anemia
    4. Neoplasms
    5. Steroids
    6. Adrenocortical hyperfunction
    7. Neurologic Disorders
      1. Multiple Sclerosis
      2. Myasthenia Gravis
      3. Gullain Barre Syndrome

Lymphocyte (C0024264)

Definition (MSH)White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each); those with characteristics of neither major class are called null cells.
Definition (CSP)white blood cells formed in the body's lymphoid tissue.
Definition (NCI)(LIM-fo-site) A type of white blood cell. Lymphocytes have a number of roles in the immune system, including the production of antibodies and other substances that fight infection and diseases.
Definition (NCI)(lim-fo-SIT-ik) Referring to lymphocytes, a type of white blood cell.
Definition (NCI)White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each); those with characteristics of neither major class are called null cells. (MSH2001)
Definition (NCI)Of or pertaining to lymphocytes.
ConceptsCell (T025)
MSHD008214
Englishlymph cell, Lymphocyte, lymphocytes, Lymphocytic, Lymphocytic cell
Spanishcelula linfatica, linfocitico, linfocito
Parent ConceptsLymphatic System (C0024235), Leukocytes (C0023516), Body part (C0229962), Leukocytes, Mononuclear (C0023517), Hematopoietic and Lymphoid Cell (C1512385), Anatomy Qualifier (C1515978), Causal appearances (C0439675), Peripheral blood mononuclear cell (C1321301)
SourcesAOD, CSP, HL7V2.5, LCH, LNC, MSH, MTH, NCI, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)


Lymphocytosis (C0024282)

Definition (MSH)Excess of normal lymphocytes in the blood or in any effusion.
Definition (CSP)excess of normal lymphocytes in the blood or in any effusion.
ConceptsDisease or Syndrome (T047)
MSHD008218
EnglishIncreased blood lymphocyte number, Lymphocytoses, Lymphocytosis
Spanishcantidad de linfocitos sanguineos elevada, linfocitosis
Parent ConceptsLeukocytosis (C0023518), RETICULOENDTHELIAL DISORDERS: NONSPECIFIC (C0549602), LYMPHOCYTES INCREASED (C0853698), Hematopoietic system finding (C1292123), Lymphocyte disorder (C0272207), White blood cell count laboratory result (C0427512), Abnormally increased cellular element of blood (C1263974), Raised hematology findings (C0586730)
SourcesAOD, COSTAR, CSP, CST, MSH, NCI, NDFRT, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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