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Acute Phase Reactant

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C-Reactive ProteinAka: CRP, High-Sensitivity CRP, hs-CRP

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  1. See Also
    1. C-Reactive Protein as Cardiac Risk Factor
  2. Dynamics
    1. Rises more than 6 hours after triggering stimulus
    2. Peaks within 50 hours
    3. Short half life of 5-7 hours
      1. Rapidly declines after condition resolves
  3. Definition
    1. Acute phase reactant
  4. Indications
    1. Detection and monitoring of diseases below
    2. Differentiating certain conditions
      1. Systemic Lupus Erythematosus
        1. CRP higher in Rheumatoid Arthritis
        2. CRP higher in other arthritis
      2. Crohn's Disease
        1. CRP higher in Ulcerative Colitis
      3. Pyelonephritis
        1. CRP lower in cystitis
      4. Bacterial infection
        1. CRP lower in viral infection
      5. Acute Bronchitis
        1. CRP lower in Asthma
  5. Increased
    1. General inflammatory conditions
      1. Inflammatory disease
      2. Infections
      3. Neoplastic disease
    2. Inflammatory disease
      1. Rheumatoid Arthritis
      2. Rheumatic Fever
      3. Inflammatory Bowel Disease
      4. Seronegative arthritis (Reiter's Syndrome)
      5. Vasculitis (e.g. Hypersensitivity Vasculitis)
    3. Detection and monitoring of infection
      1. Bacterial infection in Systemic Lupus Erythematosus
      2. Neonatal infection
      3. Postoperative infection
      4. Intercurrent infection in Leukemia
      5. Pyelonephritis
    4. Detection of Tissue Injury
      1. Myocardial Infarction
      2. Transplant rejection
      3. Neoplasia (e.g. Burkitt's Lymphoma)
    5. Cardiovascular disease risk
      1. See Cardiac Risk Factor
      2. See Cardiac Risk Management
  6. Normal conditions with elevated CRP
    1. Medications (e.g. Oral Contraceptives)
    2. Third trimester of pregnancy
  7. Efficacy
    1. Septic Arthritis
      1. CRP closely mirrors infectious process
        1. Sensitivity: 95%
        2. Kallio (1997) Pediatr Infect Dis 16:411
    2. Cardiovascular disease
      1. hs-CRP >3 mg/L predicts more ischemic episodes
        1. Rosenson (2003) Am J Cardiol 92:10i
      2. Comparatively weak predictor of heart disease
        1. Odds ratio C-RP: 1.45
        2. Odds ratio Increased SBP: 1.50
        3. Odds ratio Tobacco Abuse: 1.87
        4. Odds ratio Increased Total Cholesterol: 2.35
        5. Danesh (2004) N Engl J Med 350:1387

C-reactive protein (C0006560)

Definition (MSH)A plasma protein that circulates in increased amounts during inflammation and after tissue damage.
Definition (NCI)C-reactive protein [precursor] (224 aa, ~25 kDa) is encoded by the CRP gene. This protein is cleaved during biological activation and is associated with host defense mechanisms and inflammatory responses.
Definition (CSP)acute reactive protein that circulates in increased amounts during inflammation and after tissue damage.
ConceptsAmino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129)
MSHD002097
EnglishC Reactive Protein, C-Reactive Protein, CRP, CRP - C-reactive protein
Spanishproteina reactiva C
Parent ConceptsAcute-Phase Proteins (C0001347), Albumins (C0001924), Immunoproteins (C0021072), Globulins (C0017649)
SourcesCSP, LCH, LNC, MSH, MTH, NCI, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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