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Antithrombin III
- Indications
- Hypercoagulable state evaluation
- Normal
- Activity: 80-120% of normal activity
- Level: 17-30 mg/dl
- Increased
- Decreased
- Hereditary Antithrombin III deficiency
- Disseminated Intravascular Coagulation
- Pulmonary Embolus
- Cirrhosis
- Thrombolysis
- Chronic liver failure
- Post-surgery
- Nephrotic Syndrome
- Sepsis
- Medications
- Intravenous Heparin use longer than 3 days
- Oral Contraceptive Use
Antithrombin III (C0003438) | |
|---|---|
| Definition (MSH) | A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes; it was formerly called Antithrombin II (AT II) which has now been shown to be identical to AT III; ANTITHROMBIN III DEFICIENCY, hereditary or acquired, results in thromboembolism. It is a member of the serpin superfamily. Some authors use the term antithrombin to refer to antithrombin III. |
| Definition (CSP) | blood glycoprotein which inhibits thrombin and other blood coagulation factors; important to maintenance of normal blood fluidity. |
| Concepts | Amino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121) , Biologically Active Substance (T123) |
| MSH | D000990 |
| English | Antithrombin, Antithrombin II, Antithrombin II -RETIRED-, Antithrombin III, Antithrombin III preparation, Antithrombin III product, AT3, FACTOR XA INHIB, Factor Xa Inhibitor, Heparin Co Factor I, Heparin Co-Factor I, Heparin Cofactor I, Heparin cofactor I -RETIRED- |
| Spanish | antitrombina II, antitrombina II - RETIRADO -, antitrombina III, cofactor I de heparina - RETIRADO -, preparado con antitrombina III, preparado de antitrombina III |
| Parent Concepts | Antithrombins (C0003440), Alpha-Globulins (C0002211), Blood Coagulation Factor Inhibitors (C0524956), Blood derivative (C1629497), Plasma Proteins (C0032120), Serine Proteinase Inhibitors (C0036733), Heparin cofactor (C0313529), Duplicate concept (C1274013), Reason not stated concept (C1276325), Naturally occurring coagulation factor inhibitor (C1292277) |
| Sources | CSP, LNC, MSH, MTH, NDFRT, OMIM, RXNORM, SCTSPA, SNOMEDCT, VANDF Derived from the NIH UMLS (Unified Medical Language System) |
