Hematology and Oncology Book

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Platelet Dysfunction

Aka: Platelet Dysfunction, Platelet Bleeding Disorder, Thrombasthenia
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  1. See Also
    1. Thrombocytopenia
    2. Bleeding Disorder
    3. Drug Induced Platelet Dysfunction
    4. Coagulation Bleeding Disorders
    5. Bleeding Disorder
    6. Blood Vessel Wall Bleeding Disorders
    7. Coagulopathy in Pregnancy
    8. Clotting Pathway
  2. Signs
    1. Bleeding Disorders
    2. Purpura or Petechiae
  3. Causes: Congenital Platelet Dysfunction
    1. Von Willebrand's Disease
    2. Glanzmann's Thrombasthenia (autosomal recessive)
      1. Platelet membrane deficiency Glycoprotein IIb, IIIa
      2. Defective binding of platelet Fibrinogen
      3. Decreased platelet aggregation
    3. Bernard-Soulier Disease (autosomal recessive)
      1. Platelet membrane deficiency Glycoprotein Ib
      2. Coagulation Factor X and Factor V deficiency
      3. Large platelets and decreased platelet aggregation
    4. Storage Pool Disease
      1. Dense granule and/or alpha granule deficiency
      2. Defective platelet release of ADP and Serotonin
  4. Causes: Acquired Platelet Dysfunction
    1. See Drug Induced Platelet Dysfunction
    2. See Thrombocytopenia
      1. Idiopathic Thrombocytopenic Purpura
      2. Thrombotic Thrombocytopenic Purpura
    3. Uremia
    4. Chronic Liver Disease

Thrombasthenia (C0040015)

Definition (NCI) A rare, autosomal recessive inherited and less frequently acquired platelet disorder. It is characterized by deficient or dysfunctional glycoprotein IIb/IIIa complex. It leads to defective platelet aggregation, resulting in bleeding.
Definition (MSH) A congenital bleeding disorder with prolonged bleeding time, absence of aggregation of platelets in response to most agents, especially ADP, and impaired or absent clot retraction. Platelet membranes are deficient in or have a defect in the glycoprotein IIb-IIIa complex (PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX).
Definition (CSP) platelet abnormality characterized by defective clot formation, impaired aggregation, and prolonged bleeding time; other manifestations include nosebleeds, inappropriate bruising, and excessive bleeding.
Concepts Disease or Syndrome (T047)
MSH D013915
ICD10 D69.1
SnomedCT 32942005, 191310008, 30577005
English Glanzmann Thrombasthenia, Thrombasthenia, Glanzmann, Thrombasthenias, GLANZMANN DISEASE, THROMBASTHENIA, THROMBOASTHENIA, Thromboasthenia, thrombasthenia, Hereditary thromboasthenia, NOS, Thromboasthenia, NOS, Glanzsmann's disease, Glycoprotein IIb/IIIa defect, Heredit.haemorr.thrombasthenia, Thrombasthenia, NOS, Glanzmann's disease, Glanzmann's thrombosthenin disorder, Thrombosthenin disorder, GT, THROMBASTHENIA OF GLANZMANN AND NAEGELI, Glanzmann thrombasthenia, PLATELET GLYCOPROTEIN IIb-IIIa DEFICIENCY, PLATELET FIBRINOGEN RECEPTOR, DEFICIENCY OF, GLANZMANN THROMBASTHENIA, GLYCOPROTEIN COMPLEX IIb-IIIa, DEFICIENCY OF, GP IIb-IIIa COMPLEX, DEFICIENCY OF, Thrombasthenia, thromboasthenia (diagnosis), thromboasthenia, thrombocytasthenia, thrombocytasthenia (diagnosis), Glycoprotein IIb/IIIa defect (disorder), hereditary thromboasthenia, hereditary thromboasthenia (diagnosis), Hereditary thrombasthenia, Thrombasthenia of Glanzmann and Naegeli, Thrombasthenia [Disease/Finding], glanzmann thrombasthenia, glanzmann's thrombasthenia, glanzmann's disease, glanzmanns thrombasthenia, Platelet fibrinogen receptor, deficiency of, Platelet glycoprotein 2 b-3a deficiency, Deficiency of GP 2 b 3 a complex, Platelet Fibrinogen Receptor, Deficiency of, Glanzmann thromboasthenia, Glanzmann-Naegeli disorder, Glanzmann's syndrome, Hereditary haemorrhagic thrombasthenia, Hereditary hemorrhagic thrombasthenia, Glanzmann's thrombasthenia, Glanzmann's thrombasthenia (disorder), Hereditary thromboasthenia, Thrombasthenia, hemorrhagic, Thrombasthenia, hereditary, Thrombocytasthenia
Spanish TROMBASTENIA, Tromboastenia hereditaria, Enfermedad de Glanzmann, Tromboastenia, trombastenia de Glanzmann (trastorno), trombastenia de Glanzmann, tromboastenia hereditaria (trastorno), tromboastenia hereditaria, Glycoprotein IIb/IIIa defect, tromboastenia, trastorno de Glanzmann - Naegeli, tromboastenia de Glanzmann, Trombastenia, Trombastenia de Glanzmann
German THROMBASTHENIE, Glanzmann-Krankheit +, hereditaere Thrombasthenie, Glanzmann-Naegeli-Syndrom, Glanzmann-Thrombasthenie, Thrombasthenie
Italian Trombastenia, Tromboastenia ereditaria, Malattia di Glanzmann, Tromboastenia di Glanzmann, Tromboastenia
Dutch erfelijke trombastenie, tromboastenie, ziekte van Glanzmann, trombasthenie, Asthenie, tromb-, Glanzmann-syndroom, Trombasthenie
French Maladie de Glanzmann, Thromboasthénie, THROMBASTHENIE, Thrombasthénie héréditaire, Thrombasthénie, Purpura hémorragique héréditaire, Thrombasthénie de Glanzmann, Thrombasthénie hémorragique héréditaire
Portuguese Doença de Glanzmann, Trombastenia hereditária, TROMBOPLASTINEMIA, Trombastenia, Trombastenia de Glanzmann, Tromboastenia de Glanzmann
Swedish Trombasteni
Japanese ｲﾃﾞﾝｾｲｹｯｼｮｳﾊﾞﾝﾑﾘｮｸｼｮｳ, ｹｯｼｮｳﾊﾞﾝﾑﾘｮｸｼｮｳ, ｸﾞﾗﾝﾂﾏﾝﾋﾞｮｳ, Glanzmann血小板無力症, 血小板無力症, グランツマン病, グランツマン血小板無力症, 栓球無力症, 遺伝性血小板無力症, 栓球無力
Czech trombastenie, Dědičná trombastenie, Trombastenie, Glanzmannova nemoc
Finnish Trombastenia
Russian TROMBASTENIIA, TROMBASTENIIA GLANTSMANNA, ТРОМБАСТЕНИЯ, ТРОМБАСТЕНИЯ ГЛАНЦМАННА
Polish Tromboastenia, Trombastenia, Niewydolność płytek krwi, Zaburzenia funkcji komórek płytkowych, Zaburzenia funkcji płytek krwi
Hungarian thrombasthaenia, Öröklött thrombasthaenia, Thromboasthenia, Glanzmann-betegség
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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