Hematology and Oncology Book

Coagulopathy

Cancer

Anemia

Hemoglobinopathies

Hemolytic Disorders

Pathology and Laboratory Medicine

Blood Transfusion

Tranfusion

Lymphatic Disorders

Platelet Disorders

Obstetrics Chapter related topics

http://www.fpnotebook.com/

Azathioprine

Aka: Azathioprine, Imuran
Advertisement
  1. Indications
    1. Renal homograft maintenance
    2. Myasthenia Gravis
    3. Systemic Lupus Erythematosus (Lupus Nephritis)
    4. Acute Glomerulonephritis
  2. Pharmacology
    1. Imidazolyl derivative of mercaptopurine
      1. Metabolized to mercaptopurine as active ingredient
    2. Structural Analogue Chemotherapy (purine)
  3. Adverse effects (similar to mercaptopurine)
    1. Bone Marrow suppression
      1. Leukopenia
      2. Anemia
      3. Thrombocytopenia
    2. Skin rash
    3. Drug Fever
    4. Nausea, Vomiting or Diarrhea
    5. Hepatic dysfunction
  4. Monitoring
    1. Complete Blood Count
    2. Liver Function Tests
Medication Costs
AzaTHIOprine (on 2/9/2012 at DrugStore.com)
AzaTHIOprine 50mg Tablets #30 for $27.99 ($0.93/unit)
Imuran (on 2/9/2012 at DrugStore.com)
Imuran 50mg Tablets #30 for $180.00 ($6.00/unit)
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Azathioprine (C0004482)

Definition (CHV) an immunosppressive drug
Definition (CHV) an immunosppressive drug
Definition (CHV) an immunosppressive drug
Definition (CHV) an immunosppressive drug
Definition (MSH) An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
Definition (CSP) immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis; possible carcinogen.
Definition (NCI) A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes.
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D001379
SnomedCT 317390007, 327060009, 391800005, 111165009, 372574004
English Azathioprine, Azothioprine, 1H-Purine, 6-((1-methyl-4-nitro-1H-imidazol-5-yl)thio)-, Azathioprine [gastrointestinal], Azathioprine [gi], Azathioprine [immunosuppress], 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine, azathioprine, Azathioprine [immunosuppressant], AZTP, Azathioprine [gastrointestinal] (product), azathioprine (medication), Azathioprine [immunosuppressant] (product), Azathioprine - chemical (substance), AZATHIOPRINE, Azathioprine [Chemical/Ingredient], atps, ATP, azothioprine, azaTHIOprine, AZT - Azathioprine, Azathioprine (product), Azathioprine (substance), Azathioprine - chemical, Azathioprine [gastrointestinal] (substance), AZA
Swedish Azatioprin
Czech azathioprin
Spanish Azathioprine - chemical, Azathioprine [immunosuppressant], azatioprina (gastrointestinal) (producto), azatioprina (gastrointestinal), azatioprina (producto), azatioprina (sustancia), azatioprina, Azatioprina
Finnish Atsatiopriini
Italian Azotioprina, Azatioprina
Russian IMURAN, AZATIOPRIN, АЗАТИОПРИН, ИМУРАН
Japanese イムラン, アザチオプリン
Polish Azatiopryna
French Azathioprine
German Azathioprin
Portuguese Azatioprina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Imuran (C0699279)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D001379
English Immuran, imuran, immuran, Imuran
French Imuran
German Imuran, Immuran
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Navigation Tree