http://www.fpnotebook.com/

Monoclonal Gammopathy of Undetermined Significance

Aka: Monoclonal Gammopathy of Undetermined Significance, MGUS

Epidemiology
1. Present in 2% of patients over age 50
2. Ultimately responsible for 20% of Multiple Myeloma cases after progression
Evaluation: Factors suggesting higher risk of Multiple Myeloma progression
1. Criteria
  1. Elevated M Protein Level >1.5 g/dl
  2. Non-IgG MGUS
  3. Abnormal free light chain ratio
2. Interpretation
  1. Risk of Multiple Myeloma is 58% in 20 years if all 3 factors present
Monitoring
1. Repeat labs every 6-12 months to monitor for progression to Multiple Myeloma
Course
1. Progresses to Multiple Myeloma in 1% of cases per year

Family Practice Notebook

Patients should address specific medical concerns with their physicians.

Although access to this page is not restricted, the information found here is intended for use by medical providers.

This page was written by Scott Moses, MD, last revised on 11/10/2008 and last published on 5/14/2013.

This is one of 5887 pages in the Family Practice Notebook