Hematology and Oncology Book

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Mean Corpuscular Volume

Aka: Mean Corpuscular Volume, MCV Cutoffs for Microcytic Anemia, MCV, Mentzer Index
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  1. Findings: Normal (Units in femtoliters = 10^-15 liters)
    1. General
      1. MCV cutoffs vary from age to age
      2. MCV cutoffs also vary per reference
    2. MCV Normal Range
      1. Newborn: 95 to 121 fl
      2. Ages 6 months to 2 years: 70 to 86 fl
      3. Ages 12 to 18 years
        1. Boys: 78 - 98
        2. Girls: 78 - 102
      4. Age over 18 years: 78 to 98 fl
    3. MCV Cutoffs for Microcytic Anemia
      1. Age 1-2 years: <77 fl (CDC)
      2. Age 3-5 years: <79 fl (CDC)
      3. Age 6-11 years: <80 fl (CDC)
      4. Age 12-15 years: <82 fl (CDC)
      5. Age >15 years: <85 fl (CDC)
        1. Recommended adult microcytic MCV cutoff varies
        2. Some sources advocate MCV <78 and others <82
  2. Calculations
    1. MCV = 10 x (Hematocrit / Red Blood Cell Count)
    2. Mentzer Index = MCV / RBC Count
      1. Ratio <13: Thalassemia
      2. Ratio >13: Iron Deficiency Anemia, Hemoglobinopathy
  3. Causes: Increased MCV (See Macrocytic Anemia)
    1. Vitamin B12 Deficiency
    2. Folic Acid deficiency
    3. Alcohol Abuse
    4. Liver disease
    5. Marrow aplasia
    6. Myelofibrosis
    7. Reticulocytosis
    8. Hypothyroidism
  4. Causes: Decreased MCV (See Microcytic Anemia)
    1. Iron Deficiency Anemia
    2. Thalassemia
    3. Hemoglobinopathy
    4. Anemia of Chronic Disease
    5. Sideroblastic Anemia
    6. Chronic Renal Failure
    7. Lead Poisoning
  5. References
    1. Dallman in Hallberg (1996) Iron Nutrition, p. 65-74
    2. (1998) MMWR Morb Mortal Wkly Rep 47:1-29
      1. http://www.cdc.gov/mmwr/pdf/rr/rr4703.pdf

Mean Corpuscular Volume (result) (C0524587)

Definition (CHV) a measurement of the average size of the red blood cells
Definition (CHV) a measurement of the average size of the red blood cells
Definition (CHV) a measurement of the average size of the red blood cells
Definition (CHV) a measurement of the average size of the red blood cells
Definition (MSH) MCV equals HEMATOCRIT divided by ERYTHROCYTE COUNT.
Concepts Laboratory or Test Result (T034)
MSH D004909
SnomedCT 142868001, 365615009, 103207006
English Erythrocyte Volume, Mean Cell, Corpuscular Volumes, Mean, Erythrocyte mean corpuscular volume, MCV - Mean cell volume, MCV - NOS, Mean Corpuscular Volumes, Volume, Mean Corpuscular, Volumes, Mean Corpuscular, Mean Corpuscular Volume (result), MCV, MCV - NOS (finding), Finding of mean cell volume, mean cell volume, corpuscular mean volume, mean corpuscular volume, mean corpuscular volume (MCV), mcv, Cell Volumes, Mean, Mean Cell Volumes, Mean Cell Volume, Volume, Mean Cell, Volumes, Mean Cell, Mean cell volume, Finding of mean cell volume (finding), Mean cell volume - finding, Mean Corpuscular Volume, Erythrocyte mean corpuscular volume (observable entity)
Dutch MCV, Erytrocytenvolume, gemiddelde, Erytrocytenvolume, mean-cell
French VCM, Volume globulaire moyen, VGM (Volume Globulaire Moyen), VEM (Volume Érythrocytaire Moyen), Volume érythrocytaire moyen
German MCV, Mittleres Erythrozytenvolumen, Erythrozytenvolumen, mittleres
Italian VCM, Volume eritrocitario medio, Volume medio, Volume corpuscolare medio
Portuguese VGM, Volume Corpuscular Médio, Volume de Eritrócitos de Célula Média
Spanish VGM, volumen corpuscular medio de los glóbulos rojos, VCM, volumen corpuscular medio de los eritrocitos, MCV, volumen corpuscular eritrocítico medio, Volumen Corpuscular Medio, determinación de volumen corpuscular medio, SAI (hallazgo), determinación de volumen corpuscular medio, SAI, MCV - NOS, volumen corpuscular eritrocítico medio (entidad observable), volumen corpuscular medio - hallazgo (hallazgo), volumen corpuscular medio - hallazgo, Volumen de Eritrocitos de Celula Media, Volumen de Eritrocitos de Célula Media
Japanese ＭＣＶ, MCV
Czech Střední objem erytrocytu
Hungarian MCV
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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