II. Indications for testing
- Acute or chronic non-spherocytic Hemolytic Anemia
- Asymptomatic children with significant risk factors
- Nonphysiologic Neonatal Jaundice with risk factors
- Associated risk factors
- African, Mediterranean, or Asian ethnicity
- Family History of Jaundice, Anemia or Splenomegaly
III. Detection Methods
- Quantitative analysis
- Rapid fluorescent Spot Test
- Detects NADPH generation
IV. False Negatives
- Acute Hemolytic Anemia
- Female Heterozygotes