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Estrogen-Progesterone Challenge Test

Aka: Estrogen-Progesterone Challenge Test

See Also
1. Progesterone Challenge Test
Indications
1. Secondary Amenorrhea evaluation
2. No withdrawal bleeding with Progesterone Challenge Test
Procedure
1. Administer Estrogen-Progesterone (options below)
  1. Premarin 1.25 mg orally daily for 21 days or
  2. Oral Contraceptive for 2 Cycles or
  3. Estradiol 2 mg orally daily for 21 days and
    1. Follow with 7-10 days of Progesterone
    2. See Progesterone Challenge Test for options
2. Assess for Menstrual Bleeding after stopping medication
  1. Anticipate within 7 days of medication completion
Interpretation
1. No withdrawal bleeding occurs
  1. Suggests uterine bleeding outflow obstruction
2. Withdrawal bleeding (but not after Progesterone alone)
  1. Obtain Serum FSH and Serum LH
    1. FSH>20 and LH>40: Hypergonadotropic Hypogonadism
    2. FSH and LH<5: Hypogonadotropic Hypogonadism

Family Practice Notebook

Patients should address specific medical concerns with their physicians.

Although access to this page is not restricted, the information found here is intended for use by medical providers.

This page was written by Scott Moses, MD, last revised on 10/21/2007 and last published on 5/14/2013.

This is one of 5887 pages in the Family Practice Notebook