Endometrial Cancer Staging

Aka: Endometrial Cancer Staging

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II. Stages: International Federation of Gynecology and Obstetrics TNM System (2009)

  1. Stage I: Tumor limited to uterine corpus
    1. Stage Ia: Tumor limited to endometrium or myometrium invasion <50% (90% five year survival)
    2. Stage Ib: Myometrium invasion 50% or more (78% five year survival)
  2. Stage II: Tumor invades Cervix and uterine corpus (74% five year survival)
  3. Stage III: Tumor local or regional spread
    1. Stage IIIa: Peritoneum and serosa involvement, Adnexa may also be involved (57% five year survival)
    2. Stage IIIb: Tumor invades vagina (36% five year survival)
    3. Stage IIIc: Pelvic or para-aortic Lymph Node involvement
      1. Stage IIIc1: Regional Lymph Node metastasis to pelvic Lymph Node (57% five year survival)
      2. Stage IIIc2: Regional Lymph Node metastasis to para-aortic Lymph Nodes (49% five year survival)
  4. Stage IV: Intra-abdominal or distant metastases
    1. Stage IVa: Invasion of Bladder or bowel mucosa
    2. Stage IVb: Distant metastasis (includes intra-abdominal and inguinal Lymph Node spread)
  5. References
    1. Buchanan (2009) Am Fam Physician 80(10): 1075-88 [PubMed]

III. Stages: Older, 1988 System

  1. Stage I: Tumor limited to uterine corpus (85-91% five year survival)
    1. Stage Ia: Tumor limited to endometrium
    2. Stage Ib: Myometrium invasion <50%
    3. Stage Ic: Myometrium invasion 50% or more
  2. Stage II: Tumor invades Cervix and uterine corpus (74-83% five year survival)
    1. Stage IIa: Endocervical gland involvement
    2. Stage IIb: Invasion of cervical stroma
  3. Stage III: Tumor local or regional spread (57-66% five year survival)
    1. Stage IIIa: Peritoneum and serosa involvement (Adnexa may also be involved)
    2. Stage IIIb: Tumor invades vagina
    3. Stage IIIc: Pelvic or para-aortic Lymph Node involvement
  4. Stage IV: Intra-abdominal or distant metastases (20-25% five year survival)
    1. Stage IVa: Bladder or bowel mucosa invasion
    2. Stage IVb: Distant metastases (includes intra-abdominal and inguinal Lymph Node spread)
  5. References
    1. Creaman (2006) In J Gynaecol Obstet 95(suppl 1): S105-43 [PubMed]
    2. Sorosky (2008) Obstet Gynecol 111(2 pt 1): 436-47 [PubMed]

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