Gynecology Book

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YasminAka: Drosperinone

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  1. See Also
    1. Oral Contraceptive
    2. Progestin
  2. Indications
    1. Contraception
  3. Contraindications
    1. Renal insufficiency
    2. Hepatic insufficiency
    3. Adrenal Insufficiency
  4. Mechanism of Drosperinone
    1. Newer synthetic Progestin
    2. Lowest Androgenic Activity
      1. Marginal benefit over other low androgen OCPs
    3. Antimineralcorticoid effect (Related to Spironolactone)
      1. Only OCP Progestin with antimineralcorticoid activity
    4. AntiAndrogenic Activity similar to Progesterone
  5. Efficacy
    1. Similar to other Oral Contraceptives
  6. Formulations: Yasmin
    1. Ethinyl Estradiol 30 ug
    2. Drospirenone 3 mg (equivalent to 25 mg Spironolactone)
  7. Drug Interactions: Potassium retention effects
    1. Potassium sparing Diuretics (e.g. Spironolactone)
    2. ACE Inhibitors
    3. Angiotensin Receptor Blockers
    4. Aldosterone Antagonists
    5. Heparin
    6. Nonsteroidal Anti-inflammatory drugs
  8. Monitoring: Serum Potassium in first month
    1. Indicated if concurrent use of drugs listed above
  9. Adverse Effects
    1. See Oral Contraceptive
    2. Potassium retention (see above)
    3. May be associated with higher thromboembolism risk
  10. Advantages
    1. May be associated with less weight gain than other OCP
    2. As effective as other OCPs in Acne Vulgaris
    3. May be useful in Polycystic Ovary Disease
      1. Spironolactone used for associated Hirsutism
  11. References
    1. (2002) Med Lett Drugs Ther 44(1133):55

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