Anal Fissure

Aka: Anal Fissure

1. Pathophysiology
   1. Usually follows trauma or Diarrheal illness
   2. Chronic increase in resting anal pressure
      1. Increased anodermal blood flow causes fissures
   3. Relative ischemia in posteromedial anal region
2. Epidemiology
   1. Affects young and middle-aged adults
   2. Men and women are equally affected
3. Symptoms
   1. Onset after forced hard Bowel Movement
   2. Bright red rectal bleeding
   3. Pain during Bowel Movement
      1. Cut with sharp glass sensation
      2. Pain persists for an hour after stooling
4. Signs
   1. See Anorectal Exam
   2. Avoid Anoscopy if possible
      1. Painful and usually not needed
      2. Use Local Anesthesia if performed
   3. Crack or crevice in anoderm at anal verge
      1. Usually in canal midline (anterior or posterior)
      2. Lateral suggests other diagnosis (see differential diagnosis below)
      3. Best seen with lateral traction on opposite buttock
   4. Sentinel pile (distal Skin Tag)
      1. Tag-like swelling of fissure end
      2. Results from infection and edema
5. Differential Diagnosis
   1. See Anorectal Pain
   2. Conditions resulting in lateral Anal Fissure
      1. Inflammatory Bowel Disease (e.g. Crohn's Disease)
      2. HIV Infection
      3. Tuberculosis
      4. Syphilis
      5. Leukemia
      6. Anorectal cancer
6. Management: Medical
   1. Early Management (especially if <4 weeks)
      1. Bulk Dietary Fiber to 30 grams/day
      2. Increase fluid intake 64 ounces/day
      3. Sitz baths
      4. Topical Hydrocortisone (e.g. Proctofoam HC)
      5. Xylocaine 5%
      6. Glyceryl Trinitrate ointment (compounded by pharmacist)
         1. Apply 0.2% twice daily for 6 weeks
         2. See Rectal Nitroglycerin (Glyceryl Trinitrate, Rectiv)
         3. McLeod (2002) J Gastrointest Surg 6(3): 278-80
   2. Late Management (>3 months)
      1. Difficult to treat if persistent beyond 3 months
      2. Topical Calcium Channel Blocker
         1. Preparations (compounded by pharmacist)
            1. Topical Nifedipine 0.3% or 0.5% and Lidocaine 1.5% ointment or
            2. Topical Diltiazem 2% and Lidocaine 1.5% ointment
         2. Dosing
            1. Apply twice daily for 6 weeks
         3. Efficacy
            1. Resulted in 94.5% rate of healing
            2. Perrotti (2002) Dis Colon Rectum 45:1468-75
7. Management: Invasive procedures
   1. Indications
      1. Failure to improve after two cycles of topical Calcium Channel Blocker (see above)
   2. Lateral sphincterotomy (preferred)
      1. Efficacy
         1. Fissures heal in 96% of cases
         2. Patients satisfied in 98% of cases
      2. Complications
         1. Recurrent Anal Fissures: 8%
         2. Severe anal Incontinence: 1% (more common in women)
      3. References
         1. Nyam (1999) Dis Colon Rectum 42:1306
   3. Botulinum Toxin Injection
      1. Unclear long term efficacy
      2. Dosing
         1. Initial: Botulinum toxin 40 units
         2. Next: Botulinum toxin 40 units
      3. Adverse effects
         1. Short term Fecal Incontinence in 5-7%
         2. Long term flatus Incontinence is uncommon
      4. References
         1. Arroyo (2005) Am J Surg 189:429-34
         2. Brisinda (2007) Br J Surg 94(2): 162-7
8. References
   1. Fargo (2012) Am Fam Physician 85(6): 624-30
   2. Katsinelos (2006) Int J Colorectal Dis 21(2): 179-83
   3. Madoff (2003) Gastroenterology 124:235-45