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Reye's Syndrome
Aka: Reye's Syndrome- Pathophysiology
- Hepatic Encephalopathy in children under age 14
- Associated Conditions
- Symptoms and Signs
- Labs
- Liver Function Tests increased
- Aspartate Aminotransferase (AST) increased
- Alanine Aminotransferase (ALT) increased
- Ammonia increased
- Cerebrospinal Fluid (CSF) Normal
- Liver Function Tests increased
Reye Syndrome (C0035400) |
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| Definition (NCI) | An acute and potentially fatal metabolic disorder characterized by cerebral edema, fatty liver and hypoglycemia. It occurs primarily in children and has been associated with the use of aspirin for the treatment of viral infections. However, it can also occur in the absence of aspirin use. |
| Definition (MEDLINEPLUS) |
Reye syndrome is a rare illness that can affect the blood, liver and brain of someone who recently had a viral infection. It always follows another illness. Although it mostly affects children and teens, anyone can get it. It can develop quickly and without warning. It is most common during flu season. Symptoms include
If these symptoms occur soon after a viral illness, seek medical attention immediately. Reye syndrome can lead to a coma and brain death, so quick diagnosis and treatment are critical. Treatment focuses on preventing brain damage. There is no cure. The cause of Reye syndrome is unknown. However, studies have shown that taking aspirin increases the risk of getting it. Because of that, health care professionals now recommend other pain relievers for young patients. NIH: National Institute of Neurological Disorders and Stroke |
| Definition (NCI) | A rare disease that damages the brain and liver and causes death if not treated. It occurs most often in children younger than 15 years who have had a fever-causing virus, such as chickenpox or flu. Taking aspirin during a viral illness may increase the risk of Reye syndrome. |
| Definition (MSH) | A form of encephalopathy with fatty infiltration of the LIVER, characterized by brain EDEMA and VOMITING that may rapidly progress to SEIZURES; COMA; and DEATH. It is caused by a generalized loss of mitochondrial function leading to disturbances in fatty acid and CARNITINE metabolism. |
| Definition (CSP) | rare, acute, sometimes fatal disease of childhood, most often occurring as a sequel of varicella or a viral upper respiratory infection of childhood; marked by recurrent vomiting and elevated serum transaminase levels with distinctive changes in the liver and other viscera; an encephalopathic phase with acute brain swelling disturbances of consciousness and seizures may follow. |
| Concepts | Disease or Syndrome (T047) |
| MSH | D012202 |
| ICD9 | 331.81 |
| ICD10 | G93.7 |
| SnomedCT | 74351001, 154998003, 267688001 |
| English | Reyes' syndrome, Reye Syndrome, Reye's Syndrome, FATTY LIVER WITH ENCEPHALOPATHY, REYE SYNDROME, REYE'S SYNDROME, REYES SYNDROME, SYNDROME REYES, Reye's syndrome (diagnosis), Reyes syndrome, Syndrome Reyes, Reye Johnson Syndrome, Reye-Johnson Syndrome, Reye Syndrome [Disease/Finding], Fatty Liver with Encephalopathy, reye 's syndrome, reye syndrome, reyes syndrome, reye's syndrome, reyes's syndrome, syndrome reye, reyes syndromes, Reye's syndrome, Reye's encephalopathy, Reye syndrome, Reye's syndrome (disorder) |
| Portuguese | SINDROME DE REYE, Síndrome de Reye |
| Spanish | SINDROME DE REYE, Reye's syndrome, encefalopatía de Reye, síndrome de Reye (trastorno), síndrome de Reye, Sindrome de Reye, Síndrome de Reye |
| French | Syndrome de Reyes, SYNDROME DE REYE, Syndrome de Reye, Syndrome de Reye-Johnson |
| Swedish | Reyes syndrom |
| Japanese | ﾗｲｼｮｳｺｳｸﾞﾝ, Reye症候群, ライ症候群, レイエ症候群 |
| Czech | Reyeův syndrom, Reyův syndrom |
| Finnish | Reyen oireyhtymä |
| Russian | REIE SINDROM, РЕЙЕ СИНДРОМ |
| German | REYE SYNDROM, Reye Syndrom, Reye-Syndrom |
| Korean | 라이 증후군 |
| Polish | Zespół Reye'a |
| Hungarian | Reye syndroma, Reye-syndroma |
| Dutch | syndroom van Reye, Syndroom van Reye |
| Italian | Sindrome di Reye |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |