Gastroenterology Book

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Direct BilirubinAka: Conjugated Bilirubin, Conjugated Hyperbilirubinemia, Obstructive Jaundice

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  1. See Also
    1. Total Bilirubin (Covers physiology)
    2. Unconjugated Bilirubin
    3. Jaundice
    4. Liver Function Test
    5. Liver Function Test Abnormality
  2. Normal
    1. <0.2 mg/dl
  3. Increased Conjugated Bilirubin: Adults
    1. Intrahepatic Causes
      1. Hepatocellular disease
        1. Viral Hepatitis
        2. Alcoholic Liver Disease
      2. Biliary Tract Obstruction
      3. Drug induced cholestasis
      4. Prolonged Total Parenteral Nutrition
      5. Sarcoidosis
      6. Pregnancy
      7. Primary Biliary Cirrhosis
      8. Primary Sclerosing Cholangitis
    2. Extrahepatic Causes
      1. Cholelithiasis
      2. Pancreatitis
      3. Cryptosporidium infection (immunocompromised patient)
      4. Cytomegalovirus infection
      5. Cholangiocarcinoma
      6. Cancer involving liver
      7. Pancreatic Cancer
      8. Lymphoma
  4. Increased Conjugated Bilirubin: Neonatal Patients
    1. Sepsis
    2. Intrauterine viral infections
    3. Neonatal hepatitis
    4. Intrahepatic and extrahepatic biliary atresia
    5. Biliary tract obstruction
      1. Choledochal cyst
      2. Abdominal mass
      3. Annular pancreas
    6. Trisomy 18
    7. Galactosemia
    8. Tyrosinemia
    9. Hereditary
      1. Dubin-Johnson Syndrome
      2. Rotor's syndrome
    10. Hypermethioninemia
    11. Alpha-1 antitrypsin deficiency
    12. Cystic Fibrosis
    13. Following Hemolytic Disease of the Newborn syndrome
      1. Inspissated bile
    14. Hypopituitarism
    15. Hypothyroidism
  5. References
    1. Pasha (1996) Med Clin North Am :

Jaundice, Obstructive (C0022354)

Definition (MSH)JAUNDICE, the condition with yellowish staining of the skin and mucous membranes, that is due to impaired BILE flow in the BILIARY TRACT, such as INTRAHEPATIC CHOLESTASIS, or EXTRAHEPATIC CHOLESTASIS.
ConceptsDisease or Syndrome (T047)
MSHD041781
EnglishCHOLESTATIC JAUNDICE, Cholestatic jaundice syndrome, JAUNDICE CHOLESTATIC, Mechanical Jaundice, Obstructive hyperbilirubinaemia, Obstructive hyperbilirubinemia, Obstructive jaundice
Spanishhiperbilirrubinemia obstructiva, ictericia colestasica, ictericia obstructiva, sindrome de ictericia colestasica
Parent ConceptsLiver diseases (C0023895), BILIARY TRACT ABNORMALITY (C0549613), HEPATIC: OBSTRUCTIVE (C0549615), Icterus (C0022346), Cholestasis (C0008370), Jaundice, Obstructive (C0022354), Conjugated hyperbilirubinemia (C0268307), Obstruction of biliary tree (C0400979)
SourcesCST, DXP, MSH, MTH, NCI, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)


Bilirubin, direct measurement (C0201916)

Definition (NCI)The bilirubin is bound to glucuronide to form conjugated bilirubin (direct bilirubin). Direct Bilirubin measurement is accomplished by a colorimetric method. Direct Bilirubin in biological fluids reacts with sulfanilic acid at acidic pH to produce a red colored complex. The optical density of produced color has a direct relationship with Direct Bilirubin concentration in the solution.
Definition (NCI)A measurement of the conjugated or water-soluble bilirubin in a biological specimen.
ConceptsLaboratory Procedure (T059)
EnglishBILDIR, Direct Bilirubin, Direct Bilirubin Measurement
Spanishmedicion conjugada de bilirrubina, medicion directa de bilirrubina
Parent ConceptsChemical procedure (C0201682), Liver Function Tests (C0023901), Bilirubin measurement (C0344395), Pyrrole measurement (C1266246)
SourcesMTH, NCI, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)


Conjugated hyperbilirubinemia (C0268307)

ConceptsDisease or Syndrome (T047)
EnglishConjugated hyperbilirubinaemia, Conjugated hyperbilirubinemia
Spanishhiperbilirrubinemia conjugada, hiperbilirrubinemia directa
Parent ConceptsHyperbilirubinemia (C0020433)
SourcesOMIM, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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