II. Definition

  1. Serum transaminase marker of hepatocyte injury
  2. Less specific than ALT (present outside liver)

III. Normal

  1. Level: <35 U/L

IV. Increased

  1. See Liver Function Test Abnormality
  2. Sensitive marker for hepatocellular marker
    1. Same causes as Alanine Aminotransferase (ALT)
  3. AST is less specific then ALT (present outside liver)
    1. Heart, lung, Kidney, brain, Pancreas, muscle
    2. White Blood Cells and Red Blood Cells
  4. Liver disease causes of increased AST
    1. See Alanine Aminotransferase (ALT)
  5. Non-liver disease causes of increased AST
    1. Myocardial Infarction
    2. Myocarditis
    3. Renal Infarction
    4. Pulmonary Infarction
    5. Severe muscle Trauma
    6. Dermatomyositis
    7. Polymyositis
    8. Malignancy
    9. Seizure disorder
    10. Hyperthyroidism
    11. Celiac Sprue
    12. Hemolysis
  6. Conditions with ratio of ALT to AST > 2
    1. Alcoholism
    2. Wilson's Disease (ratio may exceed 4)

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Ontology: Aspartate Transaminase (C0004002)

Definition (MSH) Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC 2.6.1.1.
Concepts Amino Acid, Peptide, or Protein (T116) , Enzyme (T126)
MSH D001219
SnomedCT 26091008
LNC LP15426-7, LP31991-0, MTHU004883
English Aminotransferase, Aspartate, Aminotransferase, L-Aspartate-2-Oxoglutarate, Apoaminotransferase, Aspartate, Aspartate Aminotransferase, Aspartate Apoaminotransferase, Aspartate Transaminase, Glutamate-Aspartate Transaminase, Glutamic-Oxaloacetic Transaminase, L-Aspartate-2-Oxoglutarate Aminotransferase, Transaminase, Aspartate, Transaminase, Glutamate-Aspartate, Transaminase, Glutamic-Oxaloacetic, Glutamate Aspartate Transaminase, Glutamic Oxaloacetic Transaminase, L Aspartate 2 Oxoglutarate Aminotransferase, aspartate aminotransferase, L-Aspartate:2-oxoglutarate aminotransaminase, ASAT - Aspartate aminotransf, Glut oxaloacetate transam, L-asp:2-oxoglutar aminotransf, GLUTAMIC OXALOACETIC TRANS 000, transaminase A, aspartate transaminase, glutamic aspartic transaminase, glutamic oxaloacetic transaminase, S-ASAT, glutamate oxaloacetate transaminase, Aspartate Aminotransferases [Chemical/Ingredient], got, s-asat, aspartate transaminase (AST), AST, Aminotransferases, Aspartate, Aspartate Aminotransferases, ASAT - Aspartate aminotransferase, AST - Aspartate transaminase, Aspartate aminotransferase, Aspartate transaminase, GOT, Glutamate oxaloacetate transaminase, Glutamic-aspartic transaminase, Glutamic-oxaloacetic transaminase, L-aspartate:2-oxoglutarate aminotransferase, Transaminase A, Aspartate aminotransferase (substance)
Swedish Aspartataminotransferaser
Czech aspartátaminotransferasy, aspartáttransaminasa
Finnish Aspartaattiaminotransferaasit
Russian ASPARTATAMINOTRANSFERAZY, ASPARTATAMINOTRASFERAZA, GLUTAMIKOSHCHAVELEVOUKSUSNAIA TRANSAMINAZA, ASPARTATAMINOTRANSFERAZY IZOZIMY, GLUTAMIKOASPARTIKOTRANSAMINAZA, ASPARTAT-TRANSAMINAZA, ASPARTATAMINOTRANSFERAZY IZOFERMENTY, SGOT, АСПАРТАТАМИНОТРАНСФЕРАЗЫ, АСПАРТАТАМИНОТРАНСФЕРАЗЫ ИЗОЗИМЫ, АСПАРТАТАМИНОТРАНСФЕРАЗЫ ИЗОФЕРМЕНТЫ, АСПАРТАТАМИНОТРАСФЕРАЗА, АСПАРТАТ-ТРАНСАМИНАЗА, ГЛУТАМИКОАСПАРТИКОТРАНСАМИНАЗА, ГЛУТАМИКОЩАВЕЛЕВОУКСУСНАЯ ТРАНСАМИНАЗА
Japanese アスパラギン酸アミノトランスフェラーゼ, グルタミン酸-アスパラギン酸トランスアミラーゼ, トランスアミナーゼA, アスパラギン酸アミノトランスフェラーゼイソザイム, グルタミン酸-オキサロ酢酸トランスアミナーゼ, アスパラギン酸アミノトランスフェラーゼアイソザイム, アスパルテートアミノトランスフェラーゼ, グルタミック-オキサロアセティックトランスアミナーゼ, アスパラギン酸アミノトランスフェラーゼアイソエンザイム, アスパラギン酸アミノ基転移酵素, アスパラギン酸トランスアミナーゼ
Croatian ASPARTATNA AMINOTRANSFERAZA, GLUTAMIN OKSALOCTENA TRANSAMINAZA, ASPARTAT AMINOTRANSFERAZE
Polish AspAT, Aminotransferazy asparaginianowe, Aminotransferaza asparaginianowa, Transaminaza asparaginianowa
Spanish aspartato aminotransferasa (sustancia), aspartato aminotransferasa, transaminasa A, transaminasa glutámica - aspártica, transaminasa glutámica - oxaloacética, Aspartato Aminotransferasa, Aspartato Aminotransferasas, Aspartato Transaminasa, Transaminasa Glutamico-Oxaloacética
French SGOT, ASAT, GOT, Aspartate amino transferase, Aspartate aminotransferases, Glutamate-oxaloacétate transaminase, Glutamate oxaloacétique transaminase, Glutamique-aspartique transaminase, Glutamique-oxaloacétique transaminase, Sérum glutamo-oxaloacétique transaminase, Transaminase glutamique oxalo-acétique
German Aspartat-Aminotransferase, Aspartattransferase, GOT, Glutamat-Oxalacetat-Transaminase, Aspartat-Aminotransferasen
Italian Aspartato aminotransferasi
Portuguese Aspartato Aminotransferase, Aspartato Aminotransferases, Aspartato Transaminase, Transaminase Glutâmico-Oxaloacética

Ontology: SGOT - Glutamate oxaloacetate transaminase (C0242192)

Definition (NCI_NCI-GLOSS) An enzyme found in the liver, heart, and other tissues. A high level of serum glutamic-oxaloacetic transaminase released into the blood may be a sign of liver or heart damage, cancer, or other diseases.
Definition (NCI) Activity measured as a test of liver function, 46/47-kDa homodimeric human Aspartate Aminotransferases (Class-I Pyridoxal-Phosphate-Dependent Aminotransferase Family) are pyridoxal phosphate-dependent enzymes involved in amino acid metabolism and in the urea and tricarboxylic acid cycles. (NCI)
Concepts Amino Acid, Peptide, or Protein (T116) , Enzyme (T126)
MSH D001219
SnomedCT 26091008
English SGOT - Glutamate oxaloacetate transaminase, SGOT-Glut oxaloacetate transam, AST, serum glutamate oxaloacetate transaminase (SGOT), sgot, Glutamic-Oxaloacetic Transaminase, Serum, Serum Glutamic Oxaloacetic Transaminase, Serum Glutamic-Oxaloacetic Transaminase, Transaminase, Serum Glutamic-Oxaloacetic, aspartate transaminase, serum glutamic-oxaloacetic transaminase, SGOT (AST), SGOT
Portuguese SGOT
Spanish SGOT
German SGOT
Italian Transaminasi di glutammato-ossaloacetato del siero, SGOT