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HepatomegalyAka: Liver Enlargement

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  1. See Also
    1. Hepatomegaly in Newborns
    2. Splenomegaly
  2. Causes: Hepatomegaly
    1. Liver displacement (Palpable liver, no hepatomegaly)
      1. Obstructive lung disease (Asthma, COPD)
      2. Adjacent mass (Cholecystitis, abscess)
      3. Thin patient
    2. Infectious
      1. AIDS
      2. Hepatic Abscess (e.g. Amebiasis)
      3. Relapsing Fever
      4. Echinococcal cysts
      5. Schistosomiasis
      6. Kala Azar
    3. Hepatitis
      1. Alcoholic Hepatitis
      2. Autoimmune Hepatitis
      3. Viral Hepatitis
    4. Congestive hepatomegaly (often precedes edema)
      1. Congestive Heart Failure (systemic venous congestion)
      2. Constrictive Pericarditis
      3. Tricuspid stenosis
    5. Miscellaneous
      1. Wilson's Disease
      2. Fatty Liver
      3. Cirrhosis
      4. Hemochromatosis
      5. Primary Sclerosing Cholangitis
      6. Cholestasis
      7. Mixed cryoglobulinemia
      8. Congenital hepatic fibrosis
      9. Polycystic liver disease
      10. Hurler's Syndrome
      11. Gaucher's Disease
      12. Sarcoidosis
      13. Amyloidosis
    6. Malignancy
      1. Intraabdominal malignancy
      2. Pancreatic Cancer
      3. Hepatocellular Carcinoma
    7. Medication toxicity
      1. See Hepatotoxins
      2. NRTI (e.g. Stavudine)
  3. Causes: Hepatosplenomegaly
    1. See Splenomegaly
    2. Babesiosis
    3. Chaga's Disease
    4. Mononucleosis
    5. Malaria
    6. Beta Thalassemia major
    7. Essential-mixed cryoglobulinemia
    8. Viral Arthritis (e.g. Parvovirus)
    9. Severe congestive hepatomegaly (see hepatomegaly)
    10. Acute Lymphoblastic Leukemia
    11. Mast cell disorders (mastocytosis)
  4. Evaluation
    1. Step 1: Confirm liver enlargement versus displacement
    2. Step 2: Check Serum AST and Serum ALT
      1. If positive then go to step 3
      2. If negative then go to step 4
    3. Step 3: Check for Viral Hepatitis
    4. Step 4: Check Abdominal CT for liver lesion
    5. Step 5: Consider congestive hepatomegaly (e.g. CHF)
    6. Step 6: Consider liver biopsy

Hepatomegaly (C0019209)

Definition (MSH)Enlargement of the liver.
Definition (NCI)Abnormal enlargement of the liver.
ConceptsSign or Symptom (T184)
ICD9789.1, 789.1
MSHD006529
BasqueHEPATOMEGALIA
DanishHepatomegali
DutchHepatomegalie
EnglishEnlarged Liver, Enlargement of liver, hepatic enlargement, Hepatomegaly, Large liver, LIVER ENLARGEMENT
FinnishSUURENTUNUT MAKSA
FrenchHepatomegalie
GermanHepatomegalie
Hungarianhepatomegalia
ItalianEpatomegalia
NorwegianFORSTORRET LEVER/HEPATOMEGALI - r16.0 - r16.2
PortugueseHepatomegalia
Spanishhepatomegalia, higado grande
SwedishFORSTORAD LEVER
Parent ConceptsGastrointestinal tract finding (C1261141), Liver diseases (C0023895), Chronic liver disease NOS (C0341439), Other symptoms involving abdomen and pelvis (C0159065), Gastrointestinal system (C0012240), Diagnosis/Diseases Component (C0497531), Hypertrophy (C0020564), Signs and Symptoms, Digestive (C0037089), Hepatomegaly (C0019209), [D]Other abdominal or pelvic symptom (C0476316), Duplicate concept (C1274013)
SourcesAIR, AOD, COSTAR, CST, DXP, ICD9CM, ICPC, ICPCBAQ, ICPCDAN, ICPCDUT, ICPCFIN, ICPCFRE, ICPCGER, ICPCHUN, ICPCITA, ICPCNOR, ICPCPOR, ICPCSPA, ICPCSWE, MSH, MTHICD9, NCI, NDFRT, OMIM, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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