Multiple Endocrine Neoplasia Type 1

Aka: Multiple Endocrine Neoplasia Type 1, Multiple Endocrine Neoplasia Type I, Multiple Endocrine Neoplasia, Werner's Syndrome, MEN I

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II. Associated Conditions: Multiple Endocrine Neoplasia Type 1

  1. See Multiple Endocrine Neoplasia Type 2
  2. Familial Primary Hyperparathyroidism (occurs in >80% of MEN I cases)
  3. Pituitary Adenoma
  4. Pancreatic islet tumors
  5. Zollinger-Ellison Syndrome
    1. Hypergastrinemia
    2. Peptic Ulcer Disease

III. Prevention: Family Members of MEN I patients

  1. Consider annual lab screening starting at age 8 years
    1. Serum Calcium annually
    2. Consider PTH Level annually or if Serum Calcium is abnormal
    3. Malone (2004) Otolaryngol Clin North Am 37(4): 715-36 [PubMed]

IV. References

  1. Marsh (2011) Adv Otorhinolaryngol 70:84-90 [PubMed]

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