Endocrinology Book

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Glucose Challenge Test

Aka: Glucose Challenge Test
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  1. Indication: Gestational DiabetesScreening Test
    1. All pregnant patients at 24-28 weeks gestation
    2. Test with initial Prenatal Labs if indicated below
      1. Overweight patient
      2. Family History of Diabetes Mellitus
      3. Age over 30 years
      4. Prior history of Glucose Intolerance
      5. Prior pregnancy complication
        1. Fetal Macrosomia
        2. Intrauterine Fetal Demise (Stillborn)
        3. Pregnancy Induced Hypertension (PIH)
        4. Polyhydramnios
        5. Congenital defect
  2. Protocol
    1. Patient ingests 50 gram Glucola Drink
    2. Serum Glucose measured after 1 hour
  3. Interpretation
    1. Serum Glucose >130 mg/dl suggests gestation diabetes
    2. Obtain Glucose Tolerance Test 3 hour if positive
  4. Efficacy
    1. Test Sensitivity: 90% (80% if 140 mg/dl cut-off used)
    2. Test Specificity: 87%
  5. References
    1. (2001) Obstet Gynecol 98:525-38

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