Endocrinology Book

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Sexual DevelopmentAka: Puberty, Pubertal Milestone, Adrenarche, Gonadarche, Tanner Staging

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  1. Definitions
    1. Adrenarche: Increased adrenal androgen secretion
      1. Occurs between ages 6 to 8 years
      2. Transient growth spurt
      3. Some children develop axillary and pubic Hair Growth
      4. No sexual development occurs
    2. Gonadarche: GnRH released
      1. Boys
        1. LH stimulates Testosterone production
        2. FSH stimulates sperm maturation
      2. Girls
        1. FSH stimulates Estrogen and follicle formation
        2. LH stimulates corpus luteum after Ovulation
  2. Normal Development
    1. Male Tanner Stage
    2. Female Tanner Stage
  3. Abnormal Development
    1. Precocious Puberty
    2. Delayed Puberty

Endocrine disorder related to puberty (C0271522)

ConceptsDisease or Syndrome (T047)
EnglishEndocrine disorder related to puberty
Spanishenfermedad endocrina relacionada con la pubertad
Parent ConceptsDisorder of endocrine gonad (C1290845)
SourcesSCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)


sex development disorder (C0597445)

Definition (CSP)disorder or perturbation of rate or processes of sexual maturation; includes abnormalities in sexual differentiation due to the presence or absence of genetic and endocrine factors; sex determining genes dictate the gonadal sex whereas the fetal testicular hormones determine the somatic sex during sex differentiation.
ConceptsDisease or Syndrome (T047)
Englishsex development disorder
Parent Conceptsreproductive system disorder (C0178829)
SourcesCSP
Derived from the NIH UMLS (Unified Medical Language System)


Adrenarche (C0686792)

Definition (MSH)A stage of development at which the ADRENAL GLANDS undergo maturation leading to the capability of producing increasing amounts of adrenal androgens, DEHYDROEPIANDROSTERONE and ANDROSTENEDIONE. Adrenarche usually begins at about 7 or 8 years of age before the signs of PUBERTY and continues throughout puberty.
ConceptsBiologically Active Substance (T123)
MSHD050499
EnglishAdrenarche
Spanishadrenarca
Parent ConceptsPuberty (C0034011), Endocrine finding (C0559306), Puberty stage - finding (C1287066)
SourcesMSH, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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