III. Pathophysiology
- Inciting event impairs Hair Follicle mitotic and metabolic activity during Anagen phase (active phase)
IV. Causes
- Systemic conditions
- Medications
- Chemotherapy (affects 65% of patients)
- Cyclophosphamide
- Nitrosureas
- Doxorubicin (Adriamycin)
- Endocrine
- Elements
- Bismuth
- Arsenic
- Gold
- Miscellaneous
- Chemotherapy (affects 65% of patients)
V. Symptoms
- Diffuse hairs loss onset days to weeks (peaks at 1-2 months) after offending agent (often Chemotherapy)
VI. Management
- Wig until resolution
-
Hair cooling has been shown effective in Chemotherapy induced Hair Loss
- However cooling is not recommended, as it may reduce medication distribution to the scalp
VII. Course
- Typically reversible after cessation of offending agent
- Hair regrowth starts 1-3 months after stopping agent