II. Mechanism

  1. See Alpha Adrenergic Receptor
  2. Bind vasomotor receptors to inhibit sympathetic outflow
    1. Decreases peripheral vascular resistance (and Blood Pressure)
    2. Decreases Heart Rate

III. Preparations

  1. Clonidine (Catapres)
  2. Methyl-Dopa (Aldomet)
  3. Guanabenz (Wytensin)

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Cost: Medications

Methyldopa (on 6/18/2017 at Walmart.com)
Methyldopa 250mg #60 tablets for $4.00 $0.07 each
Methyldopa 250mg #180 tablets for $10.00 $0.06 each
methyldopa (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
METHYLDOPA 250 MG TABLET Generic $0.10 each
METHYLDOPA 500 MG TABLET Generic $0.27 each

Ontology: Guanabenz (C0018312)

Definition (MSH) An alpha-2 selective adrenergic agonist used as an antihypertensive agent.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D006143
SnomedCT 372867002, 82951001
English 2,6-Dichlorobenzylideneaminoguanidine, Guanabenz, 2,6 Dichlorobenzylideneaminoguanidine, Hydrazinecarboximidamide, 2-((2,6-dichlorophenyl)methylene)-, guanabenz, Guanabenz [Chemical/Ingredient], GUANABENZ, Guanabenz (product), Guanabenz (substance)
Swedish Guanabenz
Czech guanabenz
Finnish Guanabentsi
Russian GUANABENZ, ГУАНАБЕНЗ
Japanese グアナベンツ, グアナベンズ
Polish Guanabenz
Spanish guanabenz (producto), guanabenz (sustancia), guanabenz, Guanabenzo
French Guanabenz
German Guanabenz
Italian Guanabenzo
Portuguese Guanabenzo

Ontology: Wytensin (C0018313)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D006143
English Wyeth-Ayerst of Guanabenz Acetate, Wyeth Ayerst of Guanabenz Acetate, Acetate Wyeth-Ayerst, Guanabenz, Guanabenz Acetate Wyeth-Ayerst, Wytensin

Ontology: Methyldopa (C0025741)

Definition (NCI) A phenylalanine derivative and an aromatic amino acid decarboxylase inhibitor with antihypertensive activity. Methyldopa is a prodrug and is metabolized in the central nervous system. The antihypertensive action of methyldopa seems to be attributable to its conversion into alpha-methylnorepinephrine, which is a potent alpha-2 adrenergic agonist that binds to and stimulates potent central inhibitory alpha-2 adrenergic receptors. This results in a decrease in sympathetic outflow and decreased blood pressure.
Definition (MSH) An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
Concepts Pharmacologic Substance (T121) , Neuroreactive Substance or Biogenic Amine (T124) , Amino Acid, Peptide, or Protein (T116)
MSH D008750
SnomedCT 373542000, 84078002
LNC LP16200-5, MTHU016766
English Alphamethyldopa, alpha Methyl L Dopa, alpha Methyldopa, alpha-Methyl-L-Dopa, alpha-Methyldopa, methyldopa, L-Tyrosine, 3-hydroxy-alpha-methyl-, 3-Hydroxy-alpha-methyl-L-tyrosine, L-2-Amino-2-methyl-3-(3,4-dihydroxyphenyl)propionic Acid, Levo-3-(3,4-Dihydroxyphenyl)-2-methylalanine, O methyl DOPA, methyldopa (medication), Methyldopa [Chemical/Ingredient], alphamethyldopa, alpha-methyldopa, alpha methyldopa, METHYLDOPA, Methyldopa, Alpha methyldopa, Methyldopa (product), Methyldopa (substance)
Swedish Metyldopa
Czech methyldopa
Finnish Metyylidopa
Russian AL'FA-METILDOFA, METILDOPA, METILDOFA, METILDOPAT, АЛЬФА-МЕТИЛДОФА, МЕТИЛДОПА, МЕТИЛДОПАТ, МЕТИЛДОФА
Japanese α-メチルドーパ, メチルドパ, メチルドーパ, アルファ-メチルドーパ
Spanish alfa-Metildopa, metildopa (producto), metildopa (sustancia), metildopato, metildopa, Metildopa
French alpha-Méthyldopa, alpha-L-Méthyldopa, Méthyldopa
Croatian METILDOPA
Polish Metylodopa
German Alphamethyldopa, Methyldopa
Italian Metildopa
Portuguese alfa-Metildopa, Metildopa

Ontology: Central alpha-adrenoceptor agonist (C0360167)

Concepts Pharmacologic Substance (T121)
SnomedCT 349933002, 372623002
English Central alpha-adrenocep agon., Central alpha-adrenoceptor agonist, Central alpha-adrenoceptor agonist (product), Central alpha-adrenoceptor agonist (substance)
Spanish agonista central alfa adrenérgico (producto), agonista central alfa adrenérgico (sustancia), agonista central alfa adrenérgico, agonista de adrenorreceptor alfa central (sustancia), agonista de adrenorreceptor alfa central

Ontology: Aldomet (C0591055)

Concepts Pharmacologic Substance (T121) , Amino Acid, Peptide, or Protein (T116)
MSH D008750
English aldomet, Aldomet, Biopat Brand of Methyldopa, Cahill May Roberts Brand of Methyldopa, Merck Brand of Methyldopa, Merck Sharp & Dohme Brand of Methyldopa, Methyldopa Biopat Brand, Methyldopa Merck Brand