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Alpha Adrenergic Central Agonist
Aka: Alpha Adrenergic Central Agonist, Central Adrenergic Agonist, Clonidine, Catapres, Methyl-Dopa, Methyldopa, Aldomet, Guanabenz, Wytensin- See Also
- Indications (Clonidine)
- Mechanism
- Precautions
- Acute withdrawal risk (do not stop suddenly)
- Especially if Clonidine dose >1.2 mg per day
- Acute withdrawal risk (do not stop suddenly)
- Preparations
- Clonidine (Catapres)
- Start: 0.2 mg PO load
- Titrate 0.1 mg/hour to:
- Maximum of 0.7 mg
- Diastolic Blood Pressure drops more than 20 mmHg
- Methyl-Dopa (Aldomet)
- Guanabenz (Wytensin)
- Clonidine (Catapres)
| Medication Costs | ||
|---|---|---|
| CLONIDINE (on 2/10/2012 at Target.com) | ||
| CLONIDINE 0.1 MG Tablet | #30 for $4.00 | ($0.13/unit) |
| CLONIDINE 0.2 MG Tablet | #30 for $4.00 | ($0.13/unit) |
| METHYLDOPA (on 2/10/2012 at Target.com) | ||
| METHYLDOPA 250 MG* Tablet | #30 for $4.00 | ($0.13/unit) |
| METHYLDOPA 500 MG* Tablet | #30 for $4.00 | ($0.13/unit) |
| CloNIDine HCl (on 2/9/2012 at DrugStore.com) | ||
| CloNIDine HCl 0.1mg Tablets | #100 for $19.99 | ($0.20/unit) |
| CloNIDine HCl 0.3mg Tablets | #100 for $21.99 | ($0.22/unit) |
| CloNIDine HCl 0.2mg Tablets | #100 for $21.99 | ($0.22/unit) |
| CloNIDine HCl 4 0.1mg/24hr Patches Box | #1 for $109.99 | ($109.99/unit) |
| CloNIDine HCl 4 0.2mg/24hr Patches Box | #1 for $179.99 | ($179.99/unit) |
| CloNIDine HCl 4 0.3mg/24hr Patches Box | #1 for $245.97 | ($245.97/unit) |
| Catapres (on 2/9/2012 at DrugStore.com) | ||
| Catapres 0.1mg Tablets | #60 for $99.99 | ($1.67/unit) |
| Catapres 0.2mg Tablets | #60 for $154.98 | ($2.58/unit) |
| Catapres 0.3mg Tablets | #60 for $165.98 | ($2.77/unit) |
| Catapres-TTS-1 (on 2/9/2012 at DrugStore.com) | ||
| Catapres-TTS-1 4 0.1mg/24hr Patches Box | #1 for $165.98 | ($165.98/unit) |
| Catapres-TTS-2 (on 2/9/2012 at DrugStore.com) | ||
| Catapres-TTS-2 4 0.2mg/24hr Patches Box | #1 for $260.99 | ($260.99/unit) |
| Catapres-TTS-3 (on 2/9/2012 at DrugStore.com) | ||
| Catapres-TTS-3 4 0.3mg/24hr Patches Box | #1 for $359.01 | ($359.01/unit) |
| Methyldopa (on 2/9/2012 at DrugStore.com) | ||
| Methyldopa 250mg Tablets | #100 for $21.65 | ($0.22/unit) |
| Methyldopa-Hydrochlorothiazide (on 2/9/2012 at DrugStore.com) | ||
| Methyldopa-Hydrochlorothiazide 250-25mg Tablets | #60 for $22.99 | ($0.38/unit) |
| FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. | ||
Clonidine (C0009014) |
|
|---|---|
| Definition (MSH) | An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION. |
| Definition (CHV) | a hypertension treatment drug |
| Definition (NCI) | The active ingredient in a drug used to treat high blood pressure. It is also being studied in the treatment of certain types of cancer pain. It blocks the release of chemicals from nerve endings that make blood vessels constrict (get narrower). Clonidine is a type of antihypertensive agent and a type of alpha-adrenergic agonist. |
| Definition (NCI) | An imidazoline derivate and centrally-acting alpha-adrenergic agonist, with antihypertensive activity. Clonidine binds to and stimulates central alpha-2 adrenergic receptors, thereby reducing the amount of norepinephrine (NE) release and thus decreasing sympathetic outflow to the heart, kidneys, and peripheral vasculature. The reduction in sympathetic outflow leads to decreased peripheral vascular resistance, decreased blood pressure, and decreased heart rate. In addition, clonidine binds to imidazoline receptor subtype 1 (I1), which may also contribute to a reduction in blood pressure. |
| Definition (CSP) | alpha-2 adrenergic agonist that crosses the blood-brain barrier; acts centrally by reducing sympathetic tone, resulting in a fall in diastolic and systolic blood pressure and a reduction in heart rate; also acts peripherally. |
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D003000 |
| SnomedCT | 22139009, 372805007, 62782004 |
| English | Clofenil, Clonidine, Klofenil, 1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro-, N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine, clonidine, clonidine (medication), Clonidine [Chemical/Ingredient], CLONIDINE, cloNIDine, Clonidine (product), Clonidine (substance) |
| Swedish | Klonidin |
| Czech | klonidin |
| Finnish | Klonidiini |
| Russian | KHLOFAZOLIN, GEMITON, KATAPRESAN, KLOFELIN, KLONIDIN, ГЕМИТОН, КАТАПРЕСАН, КЛОНИДИН, КЛОФЕЛИН, ХЛОФАЗОЛИН |
| Japanese | クロニジン塩酸塩, カタプレス, クロニジン, 塩酸クロニジン |
| Croatian | KLONIDIN |
| Polish | Klonidyna |
| Spanish | clonidina (producto), clonidina (sustancia), clonidina, Clonidina |
| French | Clonidine |
| German | Clonidin |
| Italian | Clonidina |
| Portuguese | Clonidina |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Guanabenz (C0018312) |
|
|---|---|
| Definition (MSH) | An alpha-2 selective adrenergic agonist used as an antihypertensive agent. |
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D006143 |
| SnomedCT | 372867002, 82951001 |
| English | 2,6-Dichlorobenzylideneaminoguanidine, Guanabenz, 2,6 Dichlorobenzylideneaminoguanidine, Hydrazinecarboximidamide, 2-((2,6-dichlorophenyl)methylene)-, guanabenz, Guanabenz [Chemical/Ingredient], Guanabenz (product), Guanabenz (substance), GUANABENZ |
| Swedish | Guanabenz |
| Czech | guanabenz |
| Finnish | Guanabentsi |
| Russian | GUANABENZ, ГУАНАБЕНЗ |
| Japanese | グアナベンツ, グアナベンズ |
| Polish | Guanabenz |
| Spanish | guanabenz (producto), guanabenz (sustancia), guanabenz, Guanabenzo |
| French | Guanabenz |
| German | Guanabenz |
| Italian | Guanabenzo |
| Portuguese | Guanabenzo |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Wytensin (C0018313) |
|
|---|---|
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D006143 |
| English | Wyeth-Ayerst of Guanabenz Acetate, Wyeth Ayerst of Guanabenz Acetate, Acetate Wyeth-Ayerst, Guanabenz, Guanabenz Acetate Wyeth-Ayerst, Wytensin |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Methyldopa (C0025741) |
|
|---|---|
| Definition (MSH) | An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. |
| Definition (NCI) | A phenylalanine derivative and an aromatic amino acid decarboxylase inhibitor with antihypertensive activity. Methyldopa is a prodrug and is metabolized in the central nervous system. The antihypertensive action of methyldopa seems to be attributable to its conversion into alpha-methylnorepinephrine, which is a potent alpha-2 adrenergic agonist that binds to and stimulates potent central inhibitory alpha-2 adrenergic receptors. This results in a decrease in sympathetic outflow and decreased blood pressure. |
| Concepts | Pharmacologic Substance (T121) , Neuroreactive Substance or Biogenic Amine (T124) |
| MSH | D008750 |
| SnomedCT | 373542000, 84078002 |
| English | Alphamethyldopa, Methyldopa, alpha Methyl L Dopa, alpha Methyldopa, alpha-Methyl-L-Dopa, alpha-Methyldopa, L-Tyrosine, 3-hydroxy-alpha-methyl-, 3-Hydroxy-alpha-methyl-L-tyrosine, L-2-Amino-2-methyl-3-(3,4-dihydroxyphenyl)propionic Acid, Levo-3-(3,4-Dihydroxyphenyl)-2-methylalanine, methyldopa, O methyl DOPA, Methyldopa anhydrous, methyldopa (medication), Methyldopa [Chemical/Ingredient], alphamethyldopa, alpha-methyldopa, alpha methyldopa, METHYLDOPA, Alpha methyldopa, Methyldopa (product), Methyldopa (substance) |
| Swedish | Metyldopa |
| Czech | methyldopa |
| Finnish | Metyylidopa |
| Russian | AL'FA-METILDOFA, METILDOPA, METILDOFA, METILDOPAT, АЛЬФА-МЕТИЛДОФА, МЕТИЛДОПА, МЕТИЛДОПАТ, МЕТИЛДОФА |
| Japanese | α-メチルドーパ, メチルドパ, メチルドーパ, アルファ-メチルドーパ |
| Spanish | alfa-Metildopa, metildopa (producto), metildopa (sustancia), metildopato, metildopa, Metildopa |
| French | alpha-Méthyldopa, alpha-L-Méthyldopa, Méthyldopa |
| Croatian | METILDOPA |
| Polish | Metylodopa |
| German | Alphamethyldopa, Methyldopa |
| Italian | Metildopa |
| Portuguese | alfa-Metildopa, Metildopa |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Central alpha-adrenoceptor agonist (C0360167) |
|
|---|---|
| Concepts | Pharmacologic Substance (T121) |
| SnomedCT | 349933002, 372623002 |
| English | Central alpha-adrenocep agon., Central alpha-adrenoceptor agonist, Central alpha-adrenoceptor agonist (product), Central alpha-adrenoceptor agonist (substance) |
| Spanish | agonista central alfa adrenérgico (producto), agonista central alfa adrenérgico (sustancia), agonista central alfa adrenérgico, agonista de adrenorreceptor alfa central (sustancia), agonista de adrenorreceptor alfa central |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Aldomet (C0591055) |
|
|---|---|
| Concepts | Amino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121) |
| MSH | D008750 |
| English | aldomet, Aldomet, Biopat Brand of Methyldopa, Cahill May Roberts Brand of Methyldopa, Merck Brand of Methyldopa, Merck Sharp & Dohme Brand of Methyldopa, Methyldopa Biopat Brand, Methyldopa Merck Brand |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Catapres (C0699881) |
|
|---|---|
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D003000 |
| English | Catapresan, Catapressan, catapresan, catapres, catapre, Catapres |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |