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Creatine PhosphokinaseAka: Creatine Kinase, Creatine Phosphotransferase, CPK, CK-MB, CK-MM, CK-BB

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  1. See Also
    1. Serum Cardiac Markers
  2. Physiology
    1. Transferase class enzyme activated by Magnesium
    2. Catalyzes ATP energy storage as phosphocreatine
    3. Phosphocreatine stored in muscle and brain
    4. Phosphocreatine keeps ATP constant at Exercise start
  3. Increased
    1. Myocardial Infarction
    2. Myocarditis
    3. Rhabdomyolysis
    4. Myositis
    5. Crush injury or trauma
    6. Dermatomyositis or Polymyositis
    7. Vigorous Exercise
    8. Muscular Dystrophy
    9. Myxedema
    10. Seizure
    11. Malignant hyperthermia
    12. Intramuscular Injections
    13. Cerebrovascular Accident
    14. Pulmonary infarction
    15. Pulmonary Embolus
    16. Acute Aortic Dissection
  4. Isoenzymes:
    1. MB: Heart
    2. MM: Skeletal muscle
    3. BB:
      1. Brain
      2. Bowel infarction
      3. Neoplasm (Prostate, GI, Breast, Ovary, Lung, Brain)
  5. Protocol: Acute Coronary Syndrome Evaluation
    1. Obtain Serial CPK every 6 hours for total of 3 values
    2. Fractionate to CK-MB only if CPK increased
    3. CK-MB >5% of total CPK suggests Myocardial Infarction

Creatine Kinase (C0010287)

Definition (MSH)A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.
Definition (NCI)Encoded by human CKB Gene (ATP:Guanido Phosphotransferase Family), 381-aa 43-kDa cytoplasmic homodimer or heterodimer Creatine Kinase is a transferase involved in energy homeostasis that primarily catalyzes reversible formation of ATP and creatine from phosphocreatine. Important in muscle contraction, the reaction stores ATP energy as phosphocreatine. Three cytoplasmic isoenzymes have been identified in human tissues: MM from skeletal muscle, MB from myocardial tissue and BB from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins. (NCI)
ConceptsAmino Acid, Peptide, or Protein (T116) , Enzyme (T126)
MSHD003402
EnglishADP Phosphocreatine Phosphotransferase, ATP Creatine Phosphotransferase, CK - Creatine kinase, CKB, CPK - Creatine phosphokinase, Creatine Kinase, Creatine Kinase-B, Creatine Kinase-B Chain, Creatine Phosphokinase, EC 2.7.3.2
Spanishcreatina cinasa, creatina fosfocinasa, creatincinasa, creatinquinasa
Parent ConceptsPhosphotransferases, ATP (C0031728), other phosphotransferase (C0597145), Phosphotransferases (Nitrogenous Group Acceptor) (C0206337), PROTEIN KINASE (C0033640), Phosphotransferases (C0031727), Cardiac enzymes (C0443763)
SourcesAOD, CSP, LCH, LNC, MSH, MTH, NCI, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)


PIK3C2A gene (C1418571)

ConceptsGene or Genome (T028)
EnglishCPK, PI3K-C2alpha, PIK3C2A, PIK3C2A gene
SourcesHUGO, MTH, OMIM
Derived from the NIH UMLS (Unified Medical Language System)



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