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Wolff-Parkinson-White SyndromeAka: Wolff-Parkinson-White, WPW Syndrome

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  1. Definition
    1. Arrhythmia associated with AV bypass tract
  2. Epidemiology
    1. Prevalence: 2 per 1000 general population
  3. Pathophysiology
    1. Atrioventricular bypass tract
      1. Circumvents normal PR interval delay (up to 0.2 sec)
      2. Allows for ventricular pre-excitation
    2. Predisposes to arrhythmia
      1. Reentrant Paroxysmal Supraventricular Tachycardia
      2. Paroxysmal Atrial Fibrillation
  4. Findings: EKG changes
    1. Wide QRS (to extent that PR interval is narrowed)
    2. Narrow PR interval
      1. Due to pre-excitation of ventricle
    3. Delta wave
      1. Slurred upstroke of QRS (hockey stick appearance)
  5. Differential Diagnosis
    1. Right or Left Bundle Branch Block (wide complex)
    2. Myocardial Infarction (Q Wave when QRS negative)
  6. Precautions
    1. Do not use Digoxin or Verapamil with WPW
      1. May accelerate arrhythmia via accessory path
  7. Management
    1. See Unstable Tachycardia
  8. References
    1. Goldberger (1999) Clinical Electrocardiography, p 127-8
    2. Grauer (2001) 12 Lead EKG, p. 27

Wolff-Parkinson-White Syndrome (C0043202)

Definition (MSH)A form of ventricular pre-excitation characterized by a short PR interval and a long QRS interval with a delta wave. In this syndrome, atrial impulse conducts to the HEART VENTRICLES via an accessory pathway located between the wall of the right or left atria and the ventricles, known as the bundle of Kent. The inherited form can be caused by mutation of PRKAG2 gene encoding a gamma-2 regulatory subunit of AMP-activated protein kinase.
Definition (CSP)association of paroxysmal tachycaria or atrial fibrillation and pre-excitation characterized by a short PR interval and a long QRS interval with a delta wave.
ConceptsDisease or Syndrome (T047)
ICD9426.7
MSHD014927
EnglishVentricular pre-excitation with arrhythmia, Wolf Parkinson White Syndrome, Wolf-Parkinson-White syndrome, Wolff - Parkinson - White syndrome, WOLFF PARKINSON WHITE SYNDROME, Wolff-Park-White syndr., Wolff-Parkinson-White pattern, Wolff-Parkinson-White syndrome, WPW - Wolff-Parkinson-White pattern, WPW - Wolff-Parkinson-White syndrome, WPW Syndrome
Spanishpatron Wolff-Parkinson-White, preexcitacion ventricular con arritmia, sindrome de Wolff - Parkinson - White
Parent Conceptscardiac arrhythmia (C0003811), Syndrome (C0039082), Congenital Heart Defects (C0018798), Pre-Excitation Syndromes (C0032915), Accelerated atrioventricular conduction (C0264897), Duplicate concept (C1274013)
SourcesCOSTAR, CSP, DXP, LCH, MSH, MTH, MTHICD9, NCI, NDFRT, OMIM, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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